INT19580

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Context Info
Confidence 0.30
First Reported 1983
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 15.13
Pain Relevance 20.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
RVM 2
autonomic 2
dorsal 1
CNF 1
amygdala 1
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 243 100.00 Very High Very High Very High
Periaqueductal grey 64 100.00 Very High Very High Very High
Pain 54 100.00 Very High Very High Very High
Opioid 41 100.00 Very High Very High Very High
mu opioid receptor 39 100.00 Very High Very High Very High
Endocannabinoid 36 100.00 Very High Very High Very High
amygdala 34 100.00 Very High Very High Very High
midbrain 28 100.00 Very High Very High Very High
Endogenous opioid 6 100.00 Very High Very High Very High
Calcium channel 5 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 432 100.00 Very High Very High Very High
Pain 44 100.00 Very High Very High Very High
Nociception 34 98.04 Very High Very High Very High
Anxiety Disorder 130 96.24 Very High Very High Very High
Stress 15 94.60 High High
Hyperalgesia 8 93.04 High High
Hypertension 2 87.60 High High
Hypotension 2 86.24 High High
Lordosis 2 78.92 Quite High
Mutism 1 74.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The various functions of the PAG are interrelated and there is a significant interaction between different functional components of the PAG.
PAG Binding (interaction) of associated with central grey
1) Confidence 0.30 Published 1995 Journal Prog. Neurobiol. Section Abstract Doc Link 8545545 Disease Relevance 1.92 Pain Relevance 0.97
Recent evidence suggests: that the important functions that are classically associated with the PAG--defensive reactions, analgesia and autonomic regulation--are integrated by overlapping longitudinal columns of neurons; and that different classes of threatening or nociceptive stimuli trigger distinct co-ordinated patterns of skeletal, autonomic and antinociceptive adjustments by selectively targeting specific PAG columnar circuits.
PAG Binding (associated) of in autonomic associated with nociception, antinociceptive, central grey and analgesia
2) Confidence 0.28 Published 1994 Journal Trends Neurosci. Section Abstract Doc Link 7817403 Disease Relevance 0.65 Pain Relevance 0.60
Neuronal excitability within the PAG is likely to be regulated in a complex manner by presynaptic GABAergic and glutamatergic inputs and by direct postsynaptic actions, as previously demonstrated for ?
PAG Binding (excitability) of in Neuronal associated with neuronal excitability, gabaergic and periaqueductal grey
3) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.65 Pain Relevance 1.71
The ventral-dorsal shift of ENK immunoreactivity may (1) correspond to a somatotopic organization within the PAG or (2) mirror the topographic relationship of the PAG's interactions with other components of the endogenous analgesia system.
PAG Binding (interactions) of in dorsal associated with enkephalin, central grey and analgesia
4) Confidence 0.24 Published 1983 Journal J. Neurosci. Section Abstract Doc Link 6827311 Disease Relevance 0.79 Pain Relevance 1.71
Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception.
PAG Binding (interaction) of associated with nociception, urological neuroanatomy, opioid receptor and morphine
5) Confidence 0.19 Published 2008 Journal J. Neurochem. Section Title Doc Link 17996026 Disease Relevance 0.78 Pain Relevance 1.35
It is also concluded that the PAG, CNF, and PB do not participate directly in the tonic descending inhibitory controls, which are presumed to modulate the activity of convergent neurons.
PAG Neg (not) Binding (participate) of in CNF associated with central grey
6) Confidence 0.18 Published 1990 Journal J. Neurophysiol. Section Abstract Doc Link 2074459 Disease Relevance 0.28 Pain Relevance 0.40
in activity produced by microinjection of deltorphin into the vPAG reported
vPAG Binding (microinjection) of
7) Confidence 0.18 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2650089 Disease Relevance 0.52 Pain Relevance 1.35
WIN55,212-2 (20 nmol), which induces the internalization of PAG CB1Rs, also promoted some transfer of G?
PAG Binding (internalization) of associated with urological neuroanatomy
8) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.19 Pain Relevance 0.92
Most importantly, naloxone abolished placebo-induced coupling between rACC and PAG, which predicted both neural and behavioral placebo effects as well as activation of the RVM.
PAG Binding (coupling) of in neural associated with narcan, central grey and rostral ventromedial medulla
9) Confidence 0.14 Published 2009 Journal Neuron Section Abstract Doc Link 19709634 Disease Relevance 0.63 Pain Relevance 1.60
RESULTS: HRP retrograde tracing results showed that the striatum or accumbens nucleus connect with PAG by two pathways: 1) striatum or accumbens nucleus-->arcuate nucleus-->PAG; 2) striatum or accumbens nucleus-->habenula-->PAG.
PAG Binding (connect) of in arcuate nucleus
10) Confidence 0.14 Published 2000 Journal Acta Pharmacol. Sin. Section Body Doc Link 11324443 Disease Relevance 0 Pain Relevance 0
Male proximity therefore seems to induce analgesia in rat pups by releasing endogenous opioids that bind to mu opioid receptors in the ventrolateral PAG.
PAG Binding (bind) of associated with mu opioid receptor, endogenous opioid, central grey and analgesia
11) Confidence 0.13 Published 2000 Journal Behav. Neurosci. Section Abstract Doc Link 10718268 Disease Relevance 0.65 Pain Relevance 1.19
The PAG has a large projection to the RVM, and microinjection of morphine in the PAG increases activity of RVM Off-cells and decreases that of RVM On-cells.
PAG Binding (projection) of in RVM associated with central grey, morphine and rostral ventromedial medulla
12) Confidence 0.11 Published 1987 Journal J. Neurosci. Section Abstract Doc Link 3806198 Disease Relevance 0.71 Pain Relevance 0.78
These results provide an anatomical basis for recent behavioral and electrophysiological findings in RVM, and suggest modulatory interactions between mu and kappa opioids in PAG.
PAG Binding (interactions) of in RVM associated with central grey, opioid and rostral ventromedial medulla
13) Confidence 0.10 Published 1998 Journal Neuroreport Section Abstract Doc Link 9665599 Disease Relevance 0.65 Pain Relevance 1.16
Early work demonstrated a putative substance P connection between the LH and the PAG, but the connection is not fully defined.
PAG Binding (connection) of associated with central grey and substance p
14) Confidence 0.10 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19356605 Disease Relevance 0.73 Pain Relevance 0.99
deprivation, engages the endocannabinoid system in the dlPAG to a greater extent
dlPAG Binding (engages) of associated with endocannabinoid
15) Confidence 0.09 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593468 Disease Relevance 0.78 Pain Relevance 0.36
We further showed that the DPGi project to the vlPAG/dDpMe region and to a minor extent to the DRN and the hypothalamic region containing the hypocretin neurons [29].
vlPAG Binding (project) of in neurons
16) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.18 Pain Relevance 0.54
In this paper we review the most important findings of the last 10-15 years about the interaction between the PAG area and the cardiovascular function.
PAG Binding (interaction) of associated with central grey
17) Confidence 0.09 Published 1994 Journal Pharmacol. Res. Section Abstract Doc Link 8202441 Disease Relevance 0.98 Pain Relevance 0.38
We also observed that neurons activated by acute conspecific interaction in the PAG could be responsible for an opioid-dependent decrease in maternal behaviour as this effect was reversed by a microinjection of naltrexone, nor-binaltorphimine or naloxonazine into the lateral PAG.
PAG Binding (interaction) of in lateral associated with periaqueductal grey and opioid
18) Confidence 0.09 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17883415 Disease Relevance 0.79 Pain Relevance 0.50
lesion experiments indicate that a particular site in the PAG, at the level of
PAG Binding (indicate) of associated with central grey
19) Confidence 0.08 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.38 Pain Relevance 0.89
to the rlPAG, we have provided important information to distinguish this PAG
PAG Binding (information) of associated with central grey
20) Confidence 0.08 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.69 Pain Relevance 0.44

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