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Context Info
Confidence 0.25
First Reported 1990
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.38
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (NPHS1) plasma membrane (NPHS1) protein complex (NPHS1)
Anatomy Link Frequency
plasma 1
NPHS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
Central grey 6 99.96 Very High Very High Very High
c fibre 4 86.60 High High
cytokine 6 43.32 Quite Low
Inflammatory mediators 3 27.72 Quite Low
anesthesia 1 25.00 Low Low
parabrachial 1 25.00 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 4 100.00 Very High Very High Very High
Urological Neuroanatomy 6 99.96 Very High Very High Very High
Adhesions 6 99.84 Very High Very High Very High
Metastasis 7 98.20 Very High Very High Very High
Apoptosis 49 94.84 High High
Hypoxia 8 94.56 High High
Burns 74 93.52 High High
Acute Renal Failure 83 93.00 High High
Cancer 102 91.94 High High
Renal Disease 5 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The alterations in nephrin and cytoskeleton distribution might also account for the altered cell polarity and albumin transport across the podocyte monolayer observed after challenge with burns septic ARF group plasma.
Regulation (alterations) of nephrin in plasma associated with acute renal failure and burns
1) Confidence 0.25 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 0.91 Pain Relevance 0
Further, loss of OXPHOS genes SLC25A5, ATP6V1B1, B3, V0A4, and NDUFA4 may contribute to the self-sufficiency of the cancer cells with the ability to be less dependent on OXPHOS (2) The loss of tumor suppressor genes PTPRO, TFAP2A, CDKN1C, AIM1 and MT1G as well as other genes that were shown to suppress tumor growth in cancer cell lines but not yet identified as tumor suppressor candidates (RASD1, VDR, EHF, SPP1, ACPP, MT1F and ERBB4) contributes to insensitivity to antigrowth signals; (3) Evasion of apoptosis is mediated through loss of SPP1 and SFRP1, and activation of TUBB, NOL3 and EGLN3. (4) Two groups of genes are likely to be involved in tissue invasion and metastasis: proteolysis genes (PAPPA, PSMB9 and MARCH-1) and genes involved in cell-adhesion and/or regulation of actin cytoskeleton (CNGLN, ITPR2, NPHS1, ITGB2, CLD1, ZAK, WASF2, CD81) and (5) Angiogenesis may be mediated through ALDOA enzyme which is shown to be activated by HIF1 under hypoxic conditions and by increased glycolytic activity (Warburg effect), and which in a feedback loop activates HIF1 (Lu et al. 2002) which then activates several angiogenic factors including VEGF.
Regulation (regulation) of NPHS1 associated with hypoxia, cancer, apoptosis, adhesions and metastasis
2) Confidence 0.19 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.18 Pain Relevance 0
We conclude that the PAG, CNF, and PB, three structures that are putatively involved in the modulation of pain, do not participate directly in the supraspinal part of the loop subserving DNIC.
Neg (not) Regulation (participate) of CNF in CNF associated with pain and central grey
3) Confidence 0.01 Published 1990 Journal J. Neurophysiol. Section Abstract Doc Link 2074459 Disease Relevance 0.28 Pain Relevance 0.50

General Comments

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