INT195828

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.05
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) aging (Pla2g4a) Golgi apparatus (Pla2g4a)
endoplasmic reticulum (Pla2g4a) cytoplasmic membrane-bounded vesicle (Pla2g4a) nucleus (Pla2g4a)
Anatomy Link Frequency
lung 3
plasma 2
nerve 2
liver 1
Pla2g4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 231 99.12 Very High Very High Very High
Spinal cord 18 99.00 Very High Very High Very High
Neuropathic pain 39 96.56 Very High Very High Very High
Brush evoked pain 57 93.76 High High
Eae 12 91.32 High High
agonist 15 88.40 High High
antagonist 9 79.84 Quite High
Inflammation 12 79.40 Quite High
withdrawal 9 76.96 Quite High
Peripheral nerve injury 30 71.32 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 234 99.12 Very High Very High Very High
Nervous System Injury 132 98.24 Very High Very High Very High
Fever 118 97.70 Very High Very High Very High
Neuropathic Pain 105 96.56 Very High Very High Very High
Injury 15 91.32 High High
INFLAMMATION 20 79.40 Quite High
Targeted Disruption 2 63.44 Quite High
Pain 27 49.12 Quite Low
Hyperalgesia 3 28.60 Quite Low
Cv General 2 Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Applying ATP caused an increase in the levels of both phosphorylated cPLA2 and CaMKII in the vicinity of the plasma membrane, and physical association of these two proteins in primary cultured DRG neurons.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of cPLA2 in plasma associated with dorsal root ganglion
1) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.26 Pain Relevance 0.98
These results suggest that CaMKII is involved in cPLA2 phosphorylation and translocation in DRG neurons caused by nerve injury.
Positive_regulation (involved) of Phosphorylation (phosphorylation) of cPLA2 in nerve associated with dorsal root ganglion and nervous system injury
2) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.30 Pain Relevance 0.56
However, on day 7, the levels of phosphorylated cPLA2 (p-cPLA2) in the ipsilateral DRGs of U0126- and SB203580-treated rats were not changed compared with that in vehicle-treated rats.
Neg (not) Positive_regulation (changed) of Phosphorylation (phosphorylated) of cPLA2
3) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.16 Pain Relevance 0.44
Hence, the increased circulating level of PGE2 at the onset of the first febrile phase may be explained by the following enzymatic events in the lung and liver: production of arachidonic acid by activated (phosphorylated) cPLA2 ?
Positive_regulation (activated) of Phosphorylation (phosphorylated) of cPLA2 in lung associated with fever
4) Confidence 0.33 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.67 Pain Relevance 0.07
Hence, the increased circulating level of PGE2 at the onset of the first febrile phase may be explained by the following enzymatic events in the lung and liver: production of arachidonic acid by activated (phosphorylated) cPLA2 ?
Positive_regulation (activated) of in liver Phosphorylation (phosphorylated) of cPLA2 in lung associated with fever
5) Confidence 0.11 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.67 Pain Relevance 0.07

General Comments

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