INT195831

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 37
Disease Relevance 34.43
Pain Relevance 17.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) aging (Pla2g4a) Golgi apparatus (Pla2g4a)
endoplasmic reticulum (Pla2g4a) cytoplasmic membrane-bounded vesicle (Pla2g4a) nucleus (Pla2g4a)
Anatomy Link Frequency
plasma 6
neurons 6
lung 5
liver 4
hypothalamus 2
Pla2g4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 115 99.78 Very High Very High Very High
Brush evoked pain 437 99.66 Very High Very High Very High
dorsal root ganglion 1771 99.52 Very High Very High Very High
antagonist 69 98.84 Very High Very High Very High
Peripheral nerve injury 230 98.68 Very High Very High Very High
Neuropathic pain 299 97.76 Very High Very High Very High
Spinal cord 138 97.76 Very High Very High Very High
Inflammation 88 95.76 Very High Very High Very High
Pain 184 94.64 High High
Eae 92 90.08 High High
Disease Link Frequency Relevance Heat
Fever 826 99.80 Very High Very High Very High
Neuropathic Pain 805 99.66 Very High Very High Very High
Ganglion Cysts 1794 99.52 Very High Very High Very High
Nervous System Injury 1012 99.00 Very High Very High Very High
INFLAMMATION 144 95.76 Very High Very High Very High
Pain 207 94.64 High High
Injury 115 90.08 High High
Inflammatory Pain 23 67.44 Quite High
Hyperalgesia 23 67.24 Quite High
Cv General 2 Under Development 56 65.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, pharmacological blockade of CaMKII prevented cPLA2 phosphorylation and translocation as well as tactile allodynia following peripheral nerve injury.
Phosphorylation (phosphorylation) of cPLA2 in peripheral nerve associated with brush evoked pain, nervous system injury and peripheral nerve injury
1) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.77 Pain Relevance 1.43
Recently, it was reported that cPLA2 is phosphorylated by CaMKII in vitro [14,21].
Phosphorylation (phosphorylated) of cPLA2
2) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.26 Pain Relevance 1.17
However, on day 7, the levels of phosphorylated cPLA2 (p-cPLA2) in the ipsilateral DRGs of U0126- and SB203580-treated rats were not changed compared with that in vehicle-treated rats.
Phosphorylation (phosphorylated) of cPLA2
3) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.12 Pain Relevance 0.42
These results suggest that CaMKII is involved in cPLA2 phosphorylation and translocation in DRG neurons caused by nerve injury.
Phosphorylation (phosphorylation) of cPLA2 in nerve associated with dorsal root ganglion and nervous system injury
4) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.29 Pain Relevance 0.55
ATP receptor agonist-dependent phosphorylation of cPLA2 and CaMKII were inhibited either by the selective P2X3R/P2X2+3R antagonist A-317491 or by the nonselective VDCC blocker cadmium.
Phosphorylation (phosphorylation) of cPLA2 associated with antagonist and agonist
5) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.13 Pain Relevance 0.88
Recent evidence has indicated that CaMKII plays an important role in the phosphorylation of cPLA2 in vitro [14,21], suggesting a role for CaMKII in cPLA2 phosphorylation in injured DRG neurons.
Phosphorylation (phosphorylation) of cPLA2 in neurons associated with dorsal root ganglion
6) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.21 Pain Relevance 0.45
Applying ATP caused an increase in the levels of both phosphorylated cPLA2 and CaMKII in the vicinity of the plasma membrane, and physical association of these two proteins in primary cultured DRG neurons.
Phosphorylation (phosphorylated) of cPLA2 in plasma associated with dorsal root ganglion
7) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.24 Pain Relevance 0.97
To investigate this hypothesis, we examined co-localization of phosphorylated cPLA2 and CaMKII in DRG neurons.
Phosphorylation (phosphorylated) of cPLA2 in neurons associated with dorsal root ganglion
8) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.24 Pain Relevance 0.45
However, on day 7, the levels of phosphorylated cPLA2 (p-cPLA2) in the ipsilateral DRGs of U0126- and SB203580-treated rats were not changed compared with that in vehicle-treated rats.
Phosphorylation (phosphorylated) of p-cPLA2
9) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.12 Pain Relevance 0.43
These results suggest that the phosphorylation and translocation of cPLA2 to the plasma membrane via an interaction with activated CaMKII is a key event in the development of nerve injury-induced tactile allodynia.
Phosphorylation (phosphorylation) of cPLA2 in plasma associated with brush evoked pain and nervous system injury
10) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.86 Pain Relevance 1.45
Recent evidence has indicated that CaMKII plays an important role in the phosphorylation of cPLA2 in vitro [14,21], suggesting a role for CaMKII in cPLA2 phosphorylation in injured DRG neurons.
Phosphorylation (phosphorylation) of cPLA2 in neurons associated with dorsal root ganglion
11) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.25 Pain Relevance 0.45
We also found that DRG neurons showing translocation of both phosphorylated cPLA2 and CaMKII to the plasma membrane were observed in the injured DRG.
Phosphorylation (phosphorylated) of cPLA2 in plasma associated with dorsal root ganglion
12) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.80 Pain Relevance 1.50
Among these serine residues, phosphorylation of cPLA2 at Ser505 and Ser727 has been shown to be important for agonist-induced arachidonic acid release in mammalian cell models [11,15-17].
Phosphorylation (phosphorylation) of cPLA2 associated with agonist
13) Confidence 0.64 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.25 Pain Relevance 0.19
Activation of PGE2 synthesis at the onset of the first phase of LPS fever involves phosphorylation of cPLA2, transcriptional up-regulation of COX-2, and possibly other mechanisms.
Phosphorylation (phosphorylation) of cPLA2 associated with fever
14) Confidence 0.61 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.60 Pain Relevance 0.04
It is concluded that fever is initiated by circulating PGE2 synthesized by macrophages of the LPS-processing organs (lung and liver) via phosphorylation of cPLA2 and transcriptional up-regulation of COX-2.
Phosphorylation (phosphorylation) of cPLA2 in lung associated with fever
15) Confidence 0.61 Published 2006 Journal PLoS Biology Section Abstract Doc Link PMC1551923 Disease Relevance 0.40 Pain Relevance 0.04
The early activation of PGE2 synthesis involves phosphorylation of cPLA2 (lung) and transcriptional up-regulation of COX-2 (lung and liver).
Phosphorylation (phosphorylation) of cPLA2 in lung
16) Confidence 0.61 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.62 Pain Relevance 0.09
This activation involved phosphorylation of cytosolic phospholipase A2 (cPLA2) and transcriptional up-regulation of cyclooxygenase (COX)-2.
Phosphorylation (phosphorylation) of cytosolic phospholipase A2
17) Confidence 0.61 Published 2006 Journal PLoS Biology Section Abstract Doc Link PMC1551923 Disease Relevance 0.61 Pain Relevance 0
This activation involved phosphorylation of cytosolic phospholipase A2 (cPLA2) and transcriptional up-regulation of cyclooxygenase (COX)-2.
Phosphorylation (phosphorylation) of cPLA2
18) Confidence 0.61 Published 2006 Journal PLoS Biology Section Abstract Doc Link PMC1551923 Disease Relevance 0.61 Pain Relevance 0
Pharmacological inhibition of either p38 or extracellular signal-regulated kinase (ERK) in the injured DRG, which led to suppression of the development of tactile allodynia, did not affect cPLA2 phosphorylation and translocation after nerve injury.
Phosphorylation (phosphorylation) of cPLA2 in DRG associated with brush evoked pain, dorsal root ganglion and nervous system injury
19) Confidence 0.56 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2684092 Disease Relevance 1.66 Pain Relevance 0.92
In the present study, we investigated the involvement of MAPKs and CaMKII in cPLA2 phosphorylation and translocation in DRG neurons following peripheral nerve injury using pharmacological and molecular approaches.


Phosphorylation (phosphorylation) of cPLA2 in peripheral nerve associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
20) Confidence 0.56 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.98 Pain Relevance 0.35

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