INT195871

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.00
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (CALR) Golgi apparatus (CALR) endoplasmic reticulum (CALR)
intracellular (CALR) DNA binding (CALR) cytoplasm (CALR)
Anatomy Link Frequency
kidney 2
CALR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 40 92.64 High High
GABAergic 16 75.96 Quite High
depression 11 50.88 Quite High
cINOD 8 33.52 Quite Low
anesthesia 4 11.08 Low Low
Pain 24 5.00 Very Low Very Low Very Low
spinal inflammation 14 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
Sciatica 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 18 98.96 Very High Very High Very High
Cognitive Disorder 35 95.72 Very High Very High Very High
Death 30 95.32 Very High Very High Very High
Cancer 46 92.04 High High
Osteoporosis 3 87.96 High High
Endometriosis (extended) 1 87.28 High High
Cervical Cancer 5 82.52 Quite High
Lordosis 16 82.08 Quite High
Disease 41 74.88 Quite High
Autoimmune Disease 8 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of MT-COMP in the absence of shRNA 3B elevates CRT levels, indicating increased ER stress (Fig. 3F).
Positive_regulation (elevates) of Gene_expression (levels) of CRT associated with stress
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.57 Pain Relevance 0
In the CRT we could not observe
Neg (not) Positive_regulation (observe) of Gene_expression (observe) of CRT
2) Confidence 0.12 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1552030 Disease Relevance 0.30 Pain Relevance 0
On 6 months postoperative radiographs, average SSA was 1.8 ± 3.8 and average SACS 20.9 ± 5.8.
Positive_regulation (average) of Gene_expression (average) of SSA
3) Confidence 0.09 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896578 Disease Relevance 0.16 Pain Relevance 0
Preoperatively, average SSA was 0.5 ± 2.1 and average SACS 16.5 ± 4.0.
Positive_regulation (average) of Gene_expression (average) of SSA
4) Confidence 0.09 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896578 Disease Relevance 0.15 Pain Relevance 0
No significant overlap of HLA-B27 was observed with the ER-resident chaperone calreticulin (not shown).
Neg (No) Positive_regulation (overlap) of Neg (No) Gene_expression (overlap) of calreticulin
5) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0 Pain Relevance 0
, calcium-binding proteins such as calmodulin (presumably requiring pharmacological levels because of low affinity), calreticulin, nuclear calreticulin analogs, and two mitochondrial binding sites, one of which is located at the amphipathic ramp of complex 1 and displays high affinity to the indoleamine.19,21,43–45 The majority of synthetic agonists has not been tested for these binding sites, with the exception of ramelteon, which has a low affinity to quinone reductase 2,46 and does not seem to act via calmodulin.21
Positive_regulation (requiring) of Gene_expression (analogs) of calreticulin associated with agonist
6) Confidence 0.08 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0.14 Pain Relevance 0.12
, calcium-binding proteins such as calmodulin (presumably requiring pharmacological levels because of low affinity), calreticulin, nuclear calreticulin analogs, and two mitochondrial binding sites, one of which is located at the amphipathic ramp of complex 1 and displays high affinity to the indoleamine.19,21,43–45 The majority of synthetic agonists has not been tested for these binding sites, with the exception of ramelteon, which has a low affinity to quinone reductase 2,46 and does not seem to act via calmodulin.21
Positive_regulation (requiring) of Gene_expression (analogs) of calreticulin associated with agonist
7) Confidence 0.07 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0.14 Pain Relevance 0.12
2.0 mg/dL, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 × upper limit of normal), and kidney (serum creatinine (Crt) ?
Positive_regulation (/) of Gene_expression (/) of Crt in kidney
8) Confidence 0.05 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3014873 Disease Relevance 0.49 Pain Relevance 0.03
A similar dose-dependent potentiation of cytotoxicity was observed with increasing cisplatin concentrations and a fixed SSa concentration (10 ?
Positive_regulation (increasing) of Gene_expression (concentration) of SSa
9) Confidence 0.04 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 1.04 Pain Relevance 0

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