INT195931

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.87
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRM1, Trpv1) transport (Trpv1) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
OPRM1 (Homo sapiens)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 330 100.00 Very High Very High Very High
Morphine 159 98.32 Very High Very High Very High
qutenza 204 96.92 Very High Very High Very High
IPN 12 95.76 Very High Very High Very High
Inflammation 96 89.76 High High
Opioid 54 88.48 High High
Hyperalgesia 27 67.36 Quite High
Kinase C 42 66.24 Quite High
agonist 42 64.52 Quite High
Cannabinoid receptor 3 58.92 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 12 95.76 Very High Very High Very High
INFLAMMATION 93 89.76 High High
Hyperalgesia 36 67.36 Quite High
Neuropathic Pain 12 56.88 Quite High
Nociception 30 36.04 Quite Low
Diabetic Neuropathy 3 27.36 Quite Low
Ganglion Cysts 27 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results presented here support the hypothesis that the MOP and TRPV1 can functionally interact through a cAMP-dependent PKA pathway, as morphine inhibited FSK-potentiated capsaicin responses but not capsaicin responses in the absence of FSK.
MOP Binding (interact) of TRPV1 associated with qutenza, opioid receptor and morphine
1) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.22 Pain Relevance 1.19
This is the first demonstration of a functional interaction between the TRPV1 and the MOP at the molecular level, and the interaction demonstrated here may be of significance in the treatment of inflammatory pain.
MOP Binding (interaction) of TRPV1 associated with ipn and opioid receptor
2) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.56 Pain Relevance 1.35
The results reported in this study provide the first evidence for a functional interaction between the MOP and the TRPV1 and indicate that this interaction likely occurs via modulation of PKA-augmented TRPV1 responses.
MOP Binding (interaction) of TRPV1 associated with opioid receptor
3) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.09 Pain Relevance 0.89

General Comments

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