INT195946

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 1.03
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hprt1) transferase activity, transferring glycosyl groups (Hprt1) cytoplasm (Hprt1)
Hprt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 36 91.28 High High
Neuropeptide 11 88.80 High High
Nav1.7 3 76.88 Quite High
nociceptor 9 76.72 Quite High
Nav1.1 3 76.52 Quite High
Glutamate receptor 12 69.24 Quite High
Nav1.9 9 63.04 Quite High
sodium channel 9 62.44 Quite High
Morphine 226 56.52 Quite High
Inflammation 111 50.00 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 153 98.20 Very High Very High Very High
Nervous System Malformation 6 96.96 Very High Very High Very High
Apoptosis 57 95.00 High High
Myocardial Infarction 43 93.24 High High
Stress 13 57.76 Quite High
Coronary Heart Disease 4 54.96 Quite High
Urological Neuroanatomy 5 50.88 Quite High
INFLAMMATION 134 50.00 Quite Low
Injury 73 16.88 Low Low
Disease 6 14.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One finding that was unexpected was the significant difference in expression level of the reference genes used on the array plate (Ldha, Rplp1, Hprt, and Rpl13a).
Gene_expression (expression) of Hprt
1) Confidence 0.75 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.29 Pain Relevance 0.16
Copy number for each molecule (all P2X subunits and Lyn tyrosine kinase) was determined based on comparisons to standard curves, and for each sample, the copy number for each molecule was normalized to the expression of the endogenous housekeeping gene hypoxanthine phosphoribosyl transferase (HPRT).


Gene_expression (expression) of hypoxanthine phosphoribosyl transferase
2) Confidence 0.75 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
Primer pairs for mouse Hprt and pro-IL-1?
Gene_expression (pro) of Hprt
3) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.05 Pain Relevance 0
Expression of hypoxanthine guanine phosphoribosyl transferase 1 (Hprt1) transcript with stable level between four strains was quantified to control for variation in cDNA amounts.
Gene_expression (Expression) of hypoxanthine guanine phosphoribosyl transferase 1 associated with sprains and strains
4) Confidence 0.65 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.10 Pain Relevance 0.03
Expression of hypoxanthine guanine phosphoribosyl transferase 1 (Hprt1) transcript with a stable level between the strains and after the treatment was quantified to control for variation in cDNA amounts.
Gene_expression (Expression) of Hprt1 associated with sprains and strains
5) Confidence 0.58 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.10 Pain Relevance 0.06
The significant difference in expression of the reference genes (Rplp1, Ldha, Hprt, and Rpl13a) is also intriguing.
Gene_expression (expression) of Hprt
6) Confidence 0.58 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.06 Pain Relevance 0.05
The candidate genes Arb, Rpl32, Rpl4, Tbp, Polr2a, Hprt1, Pgk1, Ppia for each species and 18S ribosomal RNA were quantified by RT-qPCR.
Gene_expression (quantified) of Hprt1
7) Confidence 0.50 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2907514 Disease Relevance 0.44 Pain Relevance 0
Of the nine Na channels, 3 showed much higher expression relative to HPRT than the others: Nav 1.1, 1.7, and 1.8 (Figure 6A).
Gene_expression (expression) of HPRT
8) Confidence 0.28 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.28
Expression data were normalized to that of the housekeeping gene HPRT.
Gene_expression (Expression) of HPRT
9) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.28
Fluorescence was normalized with the reference dye ROX, and gene expression was normalized to the housekeeping gene hypoxanthine ribosyltransferase (HPRT; [25]), run on the same plate.
Gene_expression (ribosyltransferase) of HPRT
10) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.03

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