INT195964

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.72
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) methyltransferase activity (Comt) plasma membrane (Comt)
Anatomy Link Frequency
covering 1
Comt (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 166 100.00 Very High Very High Very High
Dopamine 64 95.44 Very High Very High Very High
Morphine 166 94.80 High High
opiate 9 92.88 High High
amygdala 6 88.28 High High
Analgesic 27 86.64 High High
Hippocampus 48 85.84 High High
Potency 6 85.84 High High
Glutamate receptor 33 80.72 Quite High
Opioid 69 80.48 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 449 99.48 Very High Very High Very High
Disease 16 98.64 Very High Very High Very High
Cognitive Disorder 29 98.28 Very High Very High Very High
Anxiety Disorder 24 96.12 Very High Very High Very High
Aggression 14 95.80 Very High Very High Very High
Congenital Anomalies 3 91.68 High High
Neurological Disease 3 83.44 Quite High
Stress 9 82.44 Quite High
Pain 11 75.36 Quite High
Targeted Disruption 8 60.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this paper we report the cloning of the cis sequence variant that controls Comt mRNA expression in many inbred strains and that produces widespread effects in the BXD family.
Transcription (expression) of Comt associated with sprains and strains
1) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.76 Pain Relevance 0.12
Interestingly, high reverse correlation among probe-sets of the same transcript was found for Atp1a2 and Comt.
Transcription (found) of Comt associated with catechol-o-methyltransferase
2) Confidence 0.70 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.58 Pain Relevance 0.57
This polymorphism (Comt1B2i; MGI:4819952) was shown to influence Comt1 mRNA abundance, protein levels, enzymatic activity, and behavioral phenotypes.
Transcription (abundance) of Comt1
3) Confidence 0.69 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2958038 Disease Relevance 0.73 Pain Relevance 0.36
This study identifies the key sequence variant that leads to differences in Comt mRNA and protein levels among mice, and that modulates synaptic function and pharmacological and behavioral traits.


Transcription (levels) of Comt
4) Confidence 0.62 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923157 Disease Relevance 0.33 Pain Relevance 0.18
Opposite profiles of hybridization signal from two probe-sets of the catechol-O-methyltransferase gene (Comt) 1449183_at (covering the last 2 exons) and 1418701_at (covering deep 3' untranslated region) were found in C57BL/6J strain. qPCR method established Comt transcript abundance to be the highest in C57BL/6J mice, which is in agreement with the results for the probe-set 1449183_at covering the corresponding mRNA region (p < 0.001).
Transcription (abundance) of Comt in covering associated with catechol-o-methyltransferase and sprains and strains
5) Confidence 0.59 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.66 Pain Relevance 0.39
One can speculate that there exist two forms of Comt mRNA different in length, corresponding to the long and short forms of transcript which were found in humans [42].
Transcription (forms) of Comt associated with catechol-o-methyltransferase
6) Confidence 0.52 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.38 Pain Relevance 1.00
Variation in Comt mRNA expression and cis-regulation in CNS and peripheral tissues
Transcription (expression) of Comt
7) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.80 Pain Relevance 0.09
Although mice lack this particular polymorphism, several recent studies have shown that variation in Comt mRNA level [9] and activity [10] between C57BL/6J (B6) and DBA/2J (D2) mouse strains is associated with differences in aggression level and morphine sensitivity, respectively.
Transcription (level) of Comt associated with aggression, sprains and strains and morphine
8) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.48 Pain Relevance 0.68

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