INT195968

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.21
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90b1) protein folding (Hsp90b1) cytosol (Hsp90b1)
endoplasmic reticulum (Hsp90b1) RNA binding (Hsp90b1) response to stress (Hsp90b1)
Anatomy Link Frequency
plasma 6
muscle 2
nervous tissue 2
muscle fibers 2
myotube 2
Hsp90b1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 10 99.76 Very High Very High Very High
cytokine 26 99.60 Very High Very High Very High
Inflammation 159 99.14 Very High Very High Very High
narcan 4 98.80 Very High Very High Very High
Morphine 54 98.68 Very High Very High Very High
opiate 3 92.48 High High
Ventral tegmentum 5 74.40 Quite High
Locus ceruleus 3 74.08 Quite High
Opioid 23 72.40 Quite High
Calcium channel 7 72.24 Quite High
Disease Link Frequency Relevance Heat
Shock 6 100.00 Very High Very High Very High
Myositis 168 99.92 Very High Very High Very High
Meningitis 40 99.68 Very High Very High Very High
INFLAMMATION 136 99.14 Very High Very High Very High
Infection 61 98.40 Very High Very High Very High
Stress 166 98.36 Very High Very High Very High
Sprains And Strains 172 96.48 Very High Very High Very High
Adhesions 12 74.64 Quite High
Disease 201 69.16 Quite High
Lymphatic System Cancer 3 55.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased Grp94 expression characterizes the endoplasmic reticulum stress-response that accompanies muscle regeneration
Positive_regulation (Increased) of Gene_expression (expression) of Grp94 in muscle associated with stress
1) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.89 Pain Relevance 0.13
Gp96 has already been reported to be a key mediator of the innate immune response due to its ability to bind pathogenic bacteria or their products.19–21 37 38 Indeed, Gp96 is a plasma membrane receptor for Vip, a Listeria monocytogenes virulence factor that is required for cell invasion and downstream signalling events.21 In addition, a Gp96 homologue, Ecgp96, the expression of which is increased during meningitis-associated E coli K1 infection of human BMECs, promotes invasion of these pathogenic bacteria.19 20 37
Positive_regulation (increased) of Gene_expression (homologue) of gp96 in plasma associated with meningitis and infection
2) Confidence 0.49 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.61 Pain Relevance 0.03
Gp96 has already been reported to be a key mediator of the innate immune response due to its ability to bind pathogenic bacteria or their products.19–21 37 38 Indeed, Gp96 is a plasma membrane receptor for Vip, a Listeria monocytogenes virulence factor that is required for cell invasion and downstream signalling events.21 In addition, a Gp96 homologue, Ecgp96, the expression of which is increased during meningitis-associated E coli K1 infection of human BMECs, promotes invasion of these pathogenic bacteria.19 20 37
Positive_regulation (required) of Gene_expression (homologue) of gp96 in plasma associated with meningitis and infection
3) Confidence 0.49 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.68 Pain Relevance 0.06
Gp96 has already been reported to be a key mediator of the innate immune response due to its ability to bind pathogenic bacteria or their products.19–21 37 38 Indeed, Gp96 is a plasma membrane receptor for Vip, a Listeria monocytogenes virulence factor that is required for cell invasion and downstream signalling events.21 In addition, a Gp96 homologue, Ecgp96, the expression of which is increased during meningitis-associated E coli K1 infection of human BMECs, promotes invasion of these pathogenic bacteria.19 20 37
Positive_regulation (required) of Gene_expression (expression) of gp96 in plasma associated with meningitis and infection
4) Confidence 0.49 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.68 Pain Relevance 0.06
Increased expression of Grp94 and calreticulin characterized patients with a high percentage of regenerating myofibers; experimental studies showed that this ER stress-response occurred simultaneously with myotube maturation, therefore lacking specificity for myositis.
Positive_regulation (Increased) of Gene_expression (expression) of Grp94 in myotube associated with stress and myositis
5) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.91 Pain Relevance 0.14
We previously reported that systemic inflammation induced by a single LPS injection did not change Grp94 expression in rabbit adult skeletal myofibers [24] - we therefore applied the same experimental protocol to the mouse to investigate whether Grp75 and calreticulin levels were affected.
Neg (not) Positive_regulation (change) of Gene_expression (expression) of Grp94 associated with inflammation
6) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.27 Pain Relevance 0.09
Nonregenerating muscle fibers from myositis patients apparently did not vary their Grp94 expression.
Neg (not) Positive_regulation (vary) of Gene_expression (expression) of Grp94 in muscle fibers associated with myositis
7) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.28 Pain Relevance 0.09
That the expression levels of GRP94, Hsp70, calnexin, and calreticulin were not changed significantly was also confirmed at the protein level.
Neg (not) Positive_regulation (changed) of Gene_expression (expression) of GRP94
8) Confidence 0.14 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0.05 Pain Relevance 0.04
Our studies have demonstrated that E. coli K1 infected MØ also exhibit increased expression of gp96, a known chaperone for TLR2 and TLR4 [28].
Positive_regulation (increased) of Gene_expression (expression) of gp96
9) Confidence 0.06 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987830 Disease Relevance 0.24 Pain Relevance 0.07
Induction of the heat shock protein 70 (Hsp1b) expression was also observed after chronic morphine treatment in mice and rats [34,38,57], and had been suggested to be associated with protection of the nervous tissue against hazardous effects of opiates [58].
Positive_regulation (Induction) of Gene_expression (expression) of Hsp1b in nervous tissue associated with shock, opiate and morphine
10) Confidence 0.06 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.59 Pain Relevance 1.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox