INT195970

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.31
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Atp1a2) transport (Atp1a2) plasma membrane (Atp1a2)
locomotion (Atp1a2) cytoplasm (Atp1a2)
Atp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 54 99.72 Very High Very High Very High
Analgesic 9 98.40 Very High Very High Very High
Migraine 101 95.60 Very High Very High Very High
gABA 11 91.20 High High
Catechol-O-methyltransferase 17 82.88 Quite High
Opioid 23 75.00 Quite High
withdrawal 10 52.92 Quite High
addiction 3 50.56 Quite High
headache 39 50.00 Quite Low
tolerance 3 49.96 Quite Low
Disease Link Frequency Relevance Heat
Vertigo 1 98.08 Very High Very High Very High
Migraine With Aura 46 95.60 Very High Very High Very High
Headache 84 91.28 High High
Sprains And Strains 75 87.84 High High
Cluster Headache 39 87.56 High High
Epilepsy 29 81.60 Quite High
Channelopathies 5 72.08 Quite High
Disease 16 36.72 Quite Low
Syndrome 7 35.76 Quite Low
Intellectual Impairment 3 26.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of correlations between gene expression and behavioural data revealed connection between the level of mRNA for K homology domain containing, RNA binding, signal transduction associated 1 (Khdrbs1) and ATPase Na+/K+ alpha2 subunit (Atp1a2) with morphine self-administration and analgesic effects, respectively.
Atp1a2 Binding (binding) of associated with analgesic and morphine
1) Confidence 0.34 Published 2006 Journal BMC Genomics Section Abstract Doc Link PMC1553451 Disease Relevance 0.37 Pain Relevance 0.51
Von Brevern et al. [62] however failed to find any CACNA1A, ATP1A2 or SCN1A mutations in patients with migrainous vertigo.
ATP1A2 Neg (failed) Binding (find) of associated with vertigo
2) Confidence 0.27 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2276243 Disease Relevance 1.94 Pain Relevance 1.14

General Comments

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