INT195977

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.74
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90b1) protein folding (Hsp90b1) cytosol (Hsp90b1)
endoplasmic reticulum (Hsp90b1) RNA binding (Hsp90b1) response to stress (Hsp90b1)
Hsp90b1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 4 97.44 Very High Very High Very High
withdrawal 10 96.56 Very High Very High Very High
Morphine 54 91.72 High High
Ventral tegmentum 5 79.16 Quite High
Locus ceruleus 3 78.84 Quite High
Opioid 23 77.16 Quite High
opiate 3 72.24 Quite High
analgesia 6 66.28 Quite High
gABA 18 59.32 Quite High
alcohol 2 29.00 Quite Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 38 100.00 Very High Very High Very High
Shock 3 99.74 Very High Very High Very High
Sprains And Strains 72 99.68 Very High Very High Very High
Malignant Neoplastic Disease 10 79.12 Quite High
Nasopharynx Cancer 72 73.92 Quite High
Cancer 48 55.24 Quite High
Stress 43 54.20 Quite High
Epstein-barr Virus 38 50.00 Quite Low
Lysosomal Storage Diseases 24 50.00 Quite Low
Infection 1 43.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protective GRP94 allele associated with bipolar disorder was related to low mRNA expression of GRP94 [14].
Transcription (expression) of GRP94 associated with manic depressive disorder
1) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.30 Pain Relevance 0
The protective GRP94 allele associated with bipolar disorder was related to low mRNA expression of GRP94 [14].
Transcription (expression) of GRP94 associated with manic depressive disorder
2) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.25 Pain Relevance 0
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Transcription (expression) of GRP94
3) Confidence 0.16 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
High concentrations of the CD63 tetraspanin were obtained in the exosome extracts constrasting with the absence of the gp96 cytoplasmic protein (Figure 2B)[21].
Neg (absence) Transcription (absence) of gp96
4) Confidence 0.13 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 0.64 Pain Relevance 0
High basal heat shock protein 1B (Hsp1b) mRNA level in SWR strain may be connected with its unusual sensitivity to naloxone-precipitated withdrawal [9].
Transcription (level) of Hsp1b associated with shock, narcan, sprains and strains and withdrawal
5) Confidence 0.06 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.55 Pain Relevance 1.27

General Comments

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