INT195978

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 11.28
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90b1) protein folding (Hsp90b1) cytosol (Hsp90b1)
endoplasmic reticulum (Hsp90b1) RNA binding (Hsp90b1) response to stress (Hsp90b1)
Anatomy Link Frequency
plasma 2
muscle 2
neurons 2
muscle fibers 2
nervous tissue 1
Hsp90b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 445 99.50 Very High Very High Very High
cytokine 51 99.20 Very High Very High Very High
Morphine 54 98.68 Very High Very High Very High
withdrawal 10 98.16 Very High Very High Very High
Inflammatory stimuli 33 97.52 Very High Very High Very High
narcan 4 97.20 Very High Very High Very High
imagery 8 96.04 Very High Very High Very High
opiate 3 92.48 High High
anesthesia 30 75.52 Quite High
Ventral tegmentum 5 72.80 Quite High
Disease Link Frequency Relevance Heat
Stress 480 100.00 Very High Very High Very High
Shock 7 99.74 Very High Very High Very High
Myositis 462 99.72 Very High Very High Very High
INFLAMMATION 390 99.00 Very High Very High Very High
Meningitis 37 98.80 Very High Very High Very High
Manic Depressive Disorder 57 97.68 Very High Very High Very High
Infection 54 97.52 Very High Very High Very High
Muscle Disease 11 96.60 Very High Very High Very High
Sprains And Strains 182 94.88 High High
Necrosis 24 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gp96 has already been reported to be a key mediator of the innate immune response due to its ability to bind pathogenic bacteria or their products.19–21 37 38 Indeed, Gp96 is a plasma membrane receptor for Vip, a Listeria monocytogenes virulence factor that is required for cell invasion and downstream signalling events.21 In addition, a Gp96 homologue, Ecgp96, the expression of which is increased during meningitis-associated E coli K1 infection of human BMECs, promotes invasion of these pathogenic bacteria.19 20 37
Gene_expression (expression) of gp96 in plasma associated with meningitis and infection
1) Confidence 0.65 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.61 Pain Relevance 0.03
Gp96 has already been reported to be a key mediator of the innate immune response due to its ability to bind pathogenic bacteria or their products.19–21 37 38 Indeed, Gp96 is a plasma membrane receptor for Vip, a Listeria monocytogenes virulence factor that is required for cell invasion and downstream signalling events.21 In addition, a Gp96 homologue, Ecgp96, the expression of which is increased during meningitis-associated E coli K1 infection of human BMECs, promotes invasion of these pathogenic bacteria.19 20 37
Gene_expression (homologue) of gp96 in plasma associated with meningitis and infection
2) Confidence 0.65 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.61 Pain Relevance 0.03
It has been shown that valproate and lithium can modulate GRP94 expression in neurons [23], raising the possibility that this interaction can also be modulated with valproate and lithium.
Gene_expression (expression) of GRP94 in neurons
3) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0
To test this idea, we measured mRNA expression levels of common ER stress response genes, GRP94, GRP78, total and spliced XBP-1, and AATF by real-time PCR.
Gene_expression (expression) of GRP94 associated with stress
4) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.70 Pain Relevance 0
Increased expression of Grp94 and calreticulin characterized patients with a high percentage of regenerating myofibers; experimental studies showed that this ER stress-response occurred simultaneously with myotube maturation, therefore lacking specificity for myositis.
Gene_expression (expression) of Grp94 in myotube associated with stress and myositis
5) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.91 Pain Relevance 0.14
The aim of the present study was therefore to investigate the stress-response ongoing in muscle fibers of patients affected with inflammatory myopathies, focusing on Grp94, calreticulin and Grp75 expression and distribution.
Gene_expression (expression) of Grp94 in muscle fibers associated with stress and inflammation
6) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.60 Pain Relevance 0.12
Increased Grp94 expression characterizes the endoplasmic reticulum stress-response that accompanies muscle regeneration
Gene_expression (expression) of Grp94 in muscle associated with stress
7) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.89 Pain Relevance 0.12
Our findings suggest that valproate and a compound that can reduce GRP94 expression in neurons may be a valuable treatment for patients with bipolar disorder.


Gene_expression (expression) of GRP94 in neurons associated with manic depressive disorder
8) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.43 Pain Relevance 0
Nonregenerating muscle fibers from myositis patients apparently did not vary their Grp94 expression.
Gene_expression (expression) of Grp94 in muscle fibers associated with myositis
9) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.28 Pain Relevance 0.09
Different patterns of immunohistochemical labeling for Grp94, Grp75 and calreticulin were detected in biopsies from the patient groups (Figures 1 and 2).
Gene_expression (detected) of Grp94
10) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.34 Pain Relevance 0
These results indicate that, in myositis patients, muscle regeneration and inflammation, in addition to MHC-I upregulation, do evoke an ER stress-response characterized by the increased expression of Grp94 and Grp75, respectively.
Gene_expression (expression) of Grp94 in muscle associated with stress, inflammation and myositis
11) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888201 Disease Relevance 0.72 Pain Relevance 0.16
The present study was undertaken to characterize in more detail the ER stress-response occurring in myofibers of patients with inflammatory myopathies, focusing on the expression and distribution of Grp94, calreticulin and Grp75, three ER chaperones involved in immunomodulation.


Gene_expression (expression) of Grp94 associated with stress and inflammation
12) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888201 Disease Relevance 0.83 Pain Relevance 0.16
We then looked for an experimental condition that would be stressful for skeletal muscle without affecting Grp94 expression in myofibers.
Gene_expression (expression) of Grp94 in skeletal muscle
13) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.28 Pain Relevance 0.09
Our study shows that a large proportion of our myositis patients displayed the presence of a multiple ER stress-response in myofibers, characterized by the differential expression of the ER chaperones Grp94 and Grp75.
Gene_expression (expression) of Grp94 associated with stress and myositis
14) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.87 Pain Relevance 0.12
We previously reported that systemic inflammation induced by a single LPS injection did not change Grp94 expression in rabbit adult skeletal myofibers [24] - we therefore applied the same experimental protocol to the mouse to investigate whether Grp75 and calreticulin levels were affected.
Gene_expression (expression) of Grp94 associated with inflammation
15) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.27 Pain Relevance 0.09
Gp96, biglycan and HMGB1 expression
Gene_expression (expression) of Gp96
16) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 0.20 Pain Relevance 0.09
Gp96 sections were subsequently incubated with avidin-biotin complex (ABComplex/HRP, DAKO, UK).
Gene_expression (sections) of Gp96
17) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 0.05 Pain Relevance 0.07
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Gene_expression (expression) of GRP94
18) Confidence 0.24 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
That the expression levels of GRP94, Hsp70, calnexin, and calreticulin were not changed significantly was also confirmed at the protein level.
Gene_expression (expression) of GRP94
19) Confidence 0.24 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0.03
At variance with Grp94, Grp75 protein levels increased significantly in myositis biopsies with negligible levels of regeneration, and especially in those displaying a restricted sarcolemmal MHC-I immunoreactivity to a few clusters of myofibers [40].
Gene_expression (levels) of Grp94 associated with myositis
20) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.80 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox