INT195983

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.93
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) methyltransferase activity (Comt) plasma membrane (Comt)
Comt (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 98 100.00 Very High Very High Very High
Glutamate receptor 11 97.64 Very High Very High Very High
Nucleus accumbens 17 87.20 High High
Hippocampus 31 74.56 Quite High
Morphine 57 72.64 Quite High
Neurotransmitter 16 63.60 Quite High
Ventral tegmentum 11 63.04 Quite High
Catecholamine 13 50.96 Quite High
Opioid 23 50.00 Quite Low
Analgesic 9 42.08 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 242 94.20 High High
Cognitive Disorder 19 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Aggression 8 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low
Dislocations 3 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mapping traits to the Comt locus
Localization (locus) of Comt
1) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.19 Pain Relevance 0.16
We found no SNPs, indels, or haplotypes that segregate with the pattern of expression for a ±2 Mb interval surrounding Comt.
Localization (surrounding) of Comt
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.43 Pain Relevance 0
UTR, contributes significantly to genetic variation in COMT protein abundance.
Localization (abundance) of COMT protein associated with catechol-o-methyltransferase
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.14 Pain Relevance 0.34
Significant LRS close to transcript position, which is an indication of cis-acting variations (LRS > 32.2, LOD > 7), was found for Atp1a2 (1434893_at, LRS = 65.48 and 1455136_at, LRS = 121.4), Kcnj9 (1450712_at, LRS = 65.22), Comt (1418701_at, LRS = 59.20 and 1449183_at, LRS = 44.95) and Grm7 (1459532_at, LRS = 33.51).
Localization (found) of Comt associated with catechol-o-methyltransferase and glutamate receptor
4) Confidence 0.64 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.18 Pain Relevance 0.26

General Comments

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