INT196006

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.24
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FLT4) plasma membrane (FLT4) nucleus (FLT4)
cytoplasm (FLT4)
Anatomy Link Frequency
lymphatic vessels 2
FLT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 26 99.00 Very High Very High Very High
cva 2 22.08 Low Low
Pain 5 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
drug abuse 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Helminth Infection 120 100.00 Very High Very High Very High
Disease 36 95.12 Very High Very High Very High
Cancer 42 94.20 High High
Lymphedema 154 92.72 High High
Intestinal Volvulus 6 72.12 Quite High
Lymphangioma 1 69.52 Quite High
Death 8 69.40 Quite High
Hydrocele 24 68.00 Quite High
Hemangioendothelioma 4 65.92 Quite High
Lymphatic Filariasis 46 62.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aims of this study were to assess (1) a 6-wk course of doxycycline for macrofilaricidal activity; (2) the effect of targeting the endosymbiotic Wolbachia in filarial worms on the levels of VEGF-C and its soluble receptor VEGFR-3 and on dilation of the supratesticular lymphatic vessels in microfilaremic patients; and (3) the effect of doxycycline treatment on clinical manifestations associated with filarial lymphedema.
Regulation (targeting) of VEGFR-3 in lymphatic vessels associated with helminth infection and lymphedema
1) Confidence 0.25 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.75 Pain Relevance 0.08
This raises the possibility that proinflammatory cytokines such as TNF and IL-1B induced by Wolbachia could affect lymphatic vessels via VEGF-C and its receptor sVEGFR-3.
Regulation (affect) of sVEGFR-3 in lymphatic vessels associated with cytokine
2) Confidence 0.22 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.65 Pain Relevance 0.19
The staining for CD34 and VEGFR-3 is most intense out of these [1].
Regulation (intense) of VEGFR-3
3) Confidence 0.04 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1555613 Disease Relevance 0.84 Pain Relevance 0

General Comments

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