INT196007

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 5.44
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FLT4) plasma membrane (FLT4) nucleus (FLT4)
cytoplasm (FLT4)
Anatomy Link Frequency
plasma 4
FLT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 78 94.28 High High
Inflammation 6 27.84 Quite Low
cva 2 27.44 Quite Low
Pain 13 5.00 Very Low Very Low Very Low
Paracetamol 12 5.00 Very Low Very Low Very Low
headache 12 5.00 Very Low Very Low Very Low
drug abuse 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphedema 462 99.84 Very High Very High Very High
Cancer 70 99.78 Very High Very High Very High
Helminth Infection 360 98.56 Very High Very High Very High
Infection 84 96.32 Very High Very High Very High
Hydrocele 72 93.52 High High
Lymphatic Filariasis 138 92.04 High High
Filariasis 36 82.04 Quite High
Disease Progression 6 80.08 Quite High
Lymphangioma 1 74.88 Quite High
Breast Cancer 6 68.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mean plasma concentrations of VEGF-C and soluble VEGFR-3 (sVEGFR-3) were significantly elevated in microfilaremic patients (p < 0.0001, Figure 3, and p = 0.0006, Figure 4, respectively) compared to endemic controls, i.e., residents of the same endemic area with no evidence of infection despite exposure to infective larvae (see also Materials and Methods).
Positive_regulation (elevated) of sVEGFR-3 in plasma associated with infection
1) Confidence 0.56 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.73 Pain Relevance 0
Mean plasma concentrations of VEGF-C and soluble VEGFR-3 (sVEGFR-3) were significantly elevated in microfilaremic patients (p < 0.0001, Figure 3, and p = 0.0006, Figure 4, respectively) compared to endemic controls, i.e., residents of the same endemic area with no evidence of infection despite exposure to infective larvae (see also Materials and Methods).
Positive_regulation (elevated) of VEGFR-3 in plasma associated with infection
2) Confidence 0.43 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.73 Pain Relevance 0
This finding, and more so the yet significantly elevated levels of sVEGFR-3 in lymphedema patients in comparison to microfilaremic patients (e.g., those with filarial infection but without overt lymphatic pathology), raises the question about the biological significance.
Positive_regulation (elevated) of sVEGFR-3 associated with lymphedema and infection
3) Confidence 0.41 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.99 Pain Relevance 0
Although both microfilaremic and lymphedema patients had elevated VEGF-C and sVEGFR-3 levels, those of sVEGFR-3 were yet significantly higher in lymphedema patients compared to non-lymphedema patients that are microfilaremic (p = 0.0024, Figure 4).
Positive_regulation (elevated) of sVEGFR-3 associated with lymphedema
4) Confidence 0.38 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 1.15 Pain Relevance 0.08
Apart from the macrofilaricidal effect by doxycycline, the second observation in this study is that plasma levels of VEGF-C and its soluble receptor, sVEGFR-3, are significantly elevated in patients infected with filarial worms, and there is a correlation between sVEGFR-3 and lymphatic dilation.
Positive_regulation (elevated) of sVEGFR-3 in plasma associated with helminth infection
5) Confidence 0.38 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.35 Pain Relevance 0
Mean plasma concentrations of VEGF-C and sVEGFR-3 (Figures 3 and 4) were significantly elevated in lymphedema patients (p = 0.0002, and p = 0.0012, respectively) compared to endemic controls.
Positive_regulation (elevated) of sVEGFR-3 in plasma associated with lymphedema
6) Confidence 0.38 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.63 Pain Relevance 0
Immunohistochemically the tumor cells are positive for Von-Willebrand factor, CD31, CD34 and vascular endothelial growth factor receptor-3 (VEGFR-3).
Positive_regulation (positive) of VEGFR-3 associated with cancer
7) Confidence 0.05 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1555613 Disease Relevance 0.84 Pain Relevance 0

General Comments

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