INT196024

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 1.88
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Bmp7) extracellular space (Bmp7)
Anatomy Link Frequency
skeletal muscles 3
epithelial cells 2
stromal cells 1
muscles 1
stem cells 1
Bmp7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal inflammation 26 99.48 Very High Very High Very High
spondylitis 1 50.00 Quite Low
anesthesia 19 5.00 Very Low Very Low Very Low
spinal stenosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 28 99.48 Very High Very High Very High
Cancer 19 98.72 Very High Very High Very High
Injury 19 98.32 Very High Very High Very High
Calcification 39 97.20 Very High Very High Very High
Osteoporosis 60 96.88 Very High Very High Very High
Ankylosis 4 92.72 High High
Heterotopic Ossification 4 92.16 High High
Toxicity 19 75.36 Quite High
Cytomegalovirus Infection 19 63.08 Quite High
Overdose 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These systems had three steps: the first was the combined gene transfer of BMP-2 and BMP-7 into epithelial cells to produce BMP-2/7.
Gene_expression (transfer) of BMP-7 in epithelial cells
1) Confidence 0.26 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
For example, a single vector that can express BMP-2 and BMP-7 simultaneously might be useful for assessing the influence of the BMP-2/7 heterodimer on osteoinductive activity in vivo.
Gene_expression (express) of BMP-7
2) Confidence 0.26 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.05 Pain Relevance 0
In contrast, we could not detect well-defined opacities in muscles that received transferred pCAGGS-BMP-7 and pCAGGs or pCAGGS alone.


Gene_expression (transferred) of BMP-7 in muscles
3) Confidence 0.26 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
In the present study, we evaluated the effect of the direct and simultaneous gene transfer of human BMP-2 and BMP-7 gene expression vectors (pCAGGS-BMP-2 and pCAGGS-BMP-7) on osteoinduction using in vivo electroporation.
Gene_expression (expression) of BMP-7
4) Confidence 0.22 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.05 Pain Relevance 0
Before our in vivo study, we carried out an in vitro experiment using the mouse myoblastic C2C12 cell line to determine whether cells directly and simultaneously transfected with the BMP-2 and BMP-7 genes would express these genes, as we hoped they would in vivo.
Gene_expression (transfected) of BMP-7
5) Confidence 0.22 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
g pCAGGS-BMP-7 were diluted in 100 ?
Gene_expression (diluted) of BMP-7
6) Confidence 0.22 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.14 Pain Relevance 0
In vitro studies showed previously that BMP purified from the conditioned medium of cultured CHO cells that were transfected with equal amounts of BMP-2 and BMP-7 expression vectors increases the ALP activity of mouse stromal cells far better than BMP purified from the medium of cells transfected with one of these vectors alone.
Gene_expression (expression) of BMP-7 in stromal cells
7) Confidence 0.22 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
The levels of BMP-2, BMP-6, and BMP-7 are high in AS patients with BMP-2 involved in early stages and BMP-6 and BMP-7 in the later stages.19)
Gene_expression (levels) of BMP-7 associated with spinal inflammation
8) Confidence 0.22 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2981776 Disease Relevance 0.64 Pain Relevance 0.30
In culture, protein purified from the supernatant of adenoviral vector-infected epithelial cells expressing both BMP-2 and BMP-7 accelerates the differentiation of preosteoblastic or premyogenic cells into osteoblastic cells [9].
Gene_expression (expressing) of BMP-7 in epithelial cells associated with osteoporosis
9) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.10 Pain Relevance 0
First, an in vitro study was carried out to confirm the expression of BMP-2 and BMP-7 following the double-gene transfer.
Gene_expression (expression) of BMP-7
10) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
Therefore, the expression of BMP-4 mRNA and its increase in the early phase might be involved with the effective bone formation seen when the BMP-2 and BMP-7 genes were simultaneously transferred into rat skeletal muscles by transcutaneous in vivo electroporation.
Gene_expression (transferred) of BMP-7 in skeletal muscles
11) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.19 Pain Relevance 0
In this study, we used an animal model to study ectopic bone formation in the skeletal muscles to examine the efficiency of simultaneous and direct BMP-2 and BMP-7 gene transfer using in vivo electroporation.
Gene_expression (transfer) of BMP-7 in skeletal muscles
12) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.17 Pain Relevance 0
Ten days after treatment, direct and simultaneous transfer of the BMP-2 and BMP-7 genes induced higher ALP activity (data not shown), and more intense calcification than did the transfer of either gene alone.
Gene_expression (transfer) of BMP-7 associated with calcification
13) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.10 Pain Relevance 0
The simultaneous transfer of BMP-2 and BMP-7 genes using in vivo electroporation induces more rapid bone formation than the transfer of either gene alone, and the increased expression of endogenous BMP-4 suggests that the rapid ossification is related to the induction of BMP-4.



Gene_expression (transfer) of BMP-7
14) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
Here, we assessed the effect of the direct and simultaneous gene transfer of BMP-2 and BMP-7 into skeletal muscles.
Gene_expression (transfer) of BMP-7 in skeletal muscles
15) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
We propose that the direct and simultaneous gene transfer of BMP-2 and BMP-7 by in vivo electroporation is more effective than the transfer of BMP-2 alone, which we explored in an earlier paper using the same conditions, such as the dose of plasmid and the size of the electrodes [5].
Gene_expression (transfer) of BMP-7
16) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.23 Pain Relevance 0
Prior to the in vivo study mentioned above, the effect of the combined direct gene transfer of BMP-2 and BMP-7 into myoblastic cells was also assessed using an in vitro gene-transfer system.


Gene_expression (transfer) of BMP-7
17) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression

Background

Gene_expression (transfer) of BMP-7
18) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Title Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
In the culture system, the simultaneous transfer of the BMP-2 and BMP-7 genes led to a much higher ALP activity in C2C12 cells than did the transfer of either gene alone.
Gene_expression (transfer) of BMP-7
19) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
Moreover, BMP-2 and BMP-7 gene transfer into the periostea to augment the alveolar ridge or fracture repair may enhance periosteal cell differentiation efficiently, because it is well known that periostea have multi-potential stem cells [29-31].
Gene_expression (transfer) of BMP-7 in stem cells
20) Confidence 0.20 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.20 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox