INT196030

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 2.55
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bmp4) anatomical structure formation involved in morphogenesis (Bmp4) extracellular space (Bmp4)
growth (Bmp4) extracellular region (Bmp4) proteinaceous extracellular matrix (Bmp4)
Anatomy Link Frequency
embryos 3
osteoprogenitor cells 1
skeletal system 1
Bmp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 8 86.88 High High
anesthesia 9 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 200 98.48 Very High Very High Very High
Osteoporosis 15 97.68 Very High Very High Very High
Gestational Diabetes 36 91.92 High High
Calcification 10 83.44 Quite High
Congenital Anomalies 32 78.16 Quite High
Apoptosis 40 75.00 Quite High
Fetal Diseases 8 37.12 Quite Low
Cytomegalovirus Infection 5 29.76 Quite Low
Stress 20 5.00 Very Low Very Low Very Low
Cancer 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased Bmp-4 levels of the embryos of STZ-induced diabetic rats suggested specific affection of the precursors of the skeletal system, which backs earlier findings of delayed and defective chondrogenesis and osteogenesis in the offspring (55).
Positive_regulation (increased) of Bmp-4 in skeletal system associated with diabetes mellitus
1) Confidence 0.62 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.57 Pain Relevance 0.04
Shh was decreased, Ret was unaltered, and Bmp-4 mRNA levels were increased in MD embryos compared with N embryos (Fig. 4).
Positive_regulation (increased) of Bmp-4 in embryos
2) Confidence 0.42 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.35 Pain Relevance 0
Thus, expression of copper zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), and sonic hedgehog homolog (Shh) were decreased, and bone morphogenetic protein-4 (Bmp-4) was increased, in the MD embryos compared with the N embryos.
Positive_regulation (increased) of Bmp-4 in embryos
3) Confidence 0.42 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584142 Disease Relevance 0.65 Pain Relevance 0
Thus, expression of copper zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), and sonic hedgehog homolog (Shh) were decreased, and bone morphogenetic protein-4 (Bmp-4) was increased, in the MD embryos compared with the N embryos.
Positive_regulation (increased) of bone morphogenetic protein-4 in embryos
4) Confidence 0.42 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584142 Disease Relevance 0.65 Pain Relevance 0
However, this is the first report that the simultaneous gene transfer by in vivo electroporation of BMP-2 and BMP-7 increases the level of BMP-4 mRNA.
Positive_regulation (increases) of BMP-4 mRNA
5) Confidence 0.24 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.10 Pain Relevance 0
In vivo, a transient elevation in the BMP-4 mRNA levels is reported in osteoprogenitor cells of the periosteum in the early stages of fracture repair [24-27].
Positive_regulation (elevation) of BMP-4 mRNA in osteoprogenitor cells
6) Confidence 0.24 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.09 Pain Relevance 0
In addition, the endogenous BMP-4 mRNA expression levels and BMP-4-expressing cells were examined, since several reports show that exogenous BMPs elevate the levels of other BMPs or BMP-4 mRNA [11-14].
Positive_regulation (elevate) of BMP-4 mRNA
7) Confidence 0.16 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.06 Pain Relevance 0
The simultaneous transfer of BMP-2 and BMP-7 genes using in vivo electroporation induces more rapid bone formation than the transfer of either gene alone, and the increased expression of endogenous BMP-4 suggests that the rapid ossification is related to the induction of BMP-4.



Positive_regulation (induction) of BMP-4
8) Confidence 0.16 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
In the group treated with the combined BMP-2 and BMP-7 genes, rat BMP-4 mRNA was expressed, and its level increased up to 3 days after gene transfer in a time-dependent manner.
Positive_regulation (increased) of BMP-4 mRNA
9) Confidence 0.16 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.08 Pain Relevance 0

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