INT196032

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 1.31
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Bmp7) extracellular space (Bmp7)
Anatomy Link Frequency
stromal cells 2
muscles 2
skeletal muscles 2
epithelial cells 2
Bmp7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal inflammation 26 99.84 Very High Very High Very High
spondylitis 1 50.00 Quite Low
anesthesia 10 5.00 Very Low Very Low Very Low
spinal stenosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 28 99.84 Very High Very High Very High
Calcification 21 97.20 Very High Very High Very High
Ankylosis 4 92.72 High High
Heterotopic Ossification 4 92.16 High High
Osteoporosis 33 82.16 Quite High
Cancer 10 79.52 Quite High
Injury 10 79.12 Quite High
Toxicity 10 75.36 Quite High
Cytomegalovirus Infection 10 63.36 Quite High
Overdose 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, we could not detect well-defined opacities in muscles that received transferred pCAGGS-BMP-7 and pCAGGs or pCAGGS alone.


Positive_regulation (transferred) of Gene_expression (transferred) of BMP-7 in muscles
1) Confidence 0.17 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
Before our in vivo study, we carried out an in vitro experiment using the mouse myoblastic C2C12 cell line to determine whether cells directly and simultaneously transfected with the BMP-2 and BMP-7 genes would express these genes, as we hoped they would in vivo.
Spec (whether) Positive_regulation (transfected) of Gene_expression (transfected) of BMP-7
2) Confidence 0.17 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
In vitro studies showed previously that BMP purified from the conditioned medium of cultured CHO cells that were transfected with equal amounts of BMP-2 and BMP-7 expression vectors increases the ALP activity of mouse stromal cells far better than BMP purified from the medium of cells transfected with one of these vectors alone.
Positive_regulation (increases) of Gene_expression (expression) of BMP-7 in stromal cells
3) Confidence 0.17 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
These systems had three steps: the first was the combined gene transfer of BMP-2 and BMP-7 into epithelial cells to produce BMP-2/7.
Positive_regulation (transfer) of Gene_expression (transfer) of BMP-7 in epithelial cells
4) Confidence 0.17 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
g pCAGGS-BMP-7 were diluted in 100 ?
Positive_regulation (pCAGGS) of Gene_expression (diluted) of BMP-7
5) Confidence 0.17 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.15 Pain Relevance 0
In the culture system, the simultaneous transfer of the BMP-2 and BMP-7 genes led to a much higher ALP activity in C2C12 cells than did the transfer of either gene alone.
Positive_regulation (transfer) of Gene_expression (transfer) of BMP-7
6) Confidence 0.16 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
Ten days after treatment, direct and simultaneous transfer of the BMP-2 and BMP-7 genes induced higher ALP activity (data not shown), and more intense calcification than did the transfer of either gene alone.
Positive_regulation (transfer) of Gene_expression (transfer) of BMP-7 associated with calcification
7) Confidence 0.16 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.10 Pain Relevance 0
Therefore, the expression of BMP-4 mRNA and its increase in the early phase might be involved with the effective bone formation seen when the BMP-2 and BMP-7 genes were simultaneously transferred into rat skeletal muscles by transcutaneous in vivo electroporation.
Positive_regulation (transferred) of Gene_expression (transferred) of BMP-7 in skeletal muscles
8) Confidence 0.16 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.19 Pain Relevance 0
In the culture system, the simultaneous transfer of the BMP-2 and BMP-7 genes led to a much higher ALP activity in C2C12 cells than did the transfer of either gene alone.
Positive_regulation (led) of Gene_expression (transfer) of BMP-7
9) Confidence 0.16 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
We propose that the direct and simultaneous gene transfer of BMP-2 and BMP-7 by in vivo electroporation is more effective than the transfer of BMP-2 alone, which we explored in an earlier paper using the same conditions, such as the dose of plasmid and the size of the electrodes [5].
Positive_regulation (transfer) of Gene_expression (transfer) of BMP-7
10) Confidence 0.16 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.23 Pain Relevance 0
The levels of BMP-2, BMP-6, and BMP-7 are high in AS patients with BMP-2 involved in early stages and BMP-6 and BMP-7 in the later stages.19)
Positive_regulation (high) of Gene_expression (levels) of BMP-7 associated with spinal inflammation
11) Confidence 0.14 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2981776 Disease Relevance 0.65 Pain Relevance 0.31

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