INT196033

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.45
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bmp4) anatomical structure formation involved in morphogenesis (Bmp4) extracellular space (Bmp4)
growth (Bmp4) extracellular region (Bmp4) proteinaceous extracellular matrix (Bmp4)
Anatomy Link Frequency
neural 2
Bmp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 28 78.96 Quite High
Spinal cord 87 58.28 Quite High
agonist 7 52.32 Quite High
allodynia 22 50.00 Quite Low
Pain 14 39.76 Quite Low
Neuropathic pain 18 27.48 Quite Low
Dorsal column 30 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 12 5.00 Very Low Very Low Very Low
c fibre 10 5.00 Very Low Very Low Very Low
dorsal root ganglion 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 6 99.46 Very High Very High Very High
Cicatrix 12 88.52 High High
Injury 136 83.76 Quite High
Spinal Cord Injury 67 58.28 Quite High
Neuropathic Pain 40 50.00 Quite Low
Syndrome 9 40.16 Quite Low
Pain 11 39.76 Quite Low
Calcification 4 26.16 Quite Low
Hyperalgesia 12 5.00 Very Low Very Low Very Low
Ganglion Cysts 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with previous observations of the effects of BMP on Olig2 expression in cortical neural progenitors [19], GRPs exposed to BMP-4 downregulated Olig2 expression (Figure 3a).
Negative_regulation (downregulated) of Gene_expression (expression) of BMP-4 in neural
1) Confidence 0.21 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.28 Pain Relevance 0.09
Under conditions of normal osteoblastic cell differentiation, rat BMP-4 mRNA is expressed in the early phase with peak expression levels during the proliferation and matrix formation phases, but it declines afterwards in FRC cells [10,23].
Negative_regulation (declines) of Gene_expression (expressed) of BMP-4 mRNA associated with osteoporosis
2) Confidence 0.15 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.10 Pain Relevance 0
On the other hand, BMP-2 inhibits BMP-4 mRNA expression initially, but stimulates it during the mineralization phase [11,13].
Negative_regulation (inhibits) of Gene_expression (expression) of BMP-4 mRNA
3) Confidence 0.15 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.07 Pain Relevance 0

General Comments

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