INT196034

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.63
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bmp4) anatomical structure formation involved in morphogenesis (Bmp4) extracellular space (Bmp4)
growth (Bmp4) extracellular region (Bmp4) proteinaceous extracellular matrix (Bmp4)
Anatomy Link Frequency
chondrocytes 2
neural 2
Bmp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 2 34.00 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 50 96.20 Very High Very High Very High
Osteoporosis 9 82.16 Quite High
Calcification 6 74.56 Quite High
Gestational Diabetes 9 67.96 Quite High
Apoptosis 10 50.00 Quite Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, since isolated neural stem cells exposed to glucose in vitro show increased gene expression of both Shh and Bmp-4 (50), the exact relationship(s) between gene expression changes in the surrounding tissues and the neural crest cells themselves caused by exposure to a diabetic environment will have be subject to further studies.
Positive_regulation (increased) of Gene_expression (expression) of Bmp-4 in neural associated with diabetes mellitus
1) Confidence 0.45 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.48 Pain Relevance 0
In the costochondral growth-plate chondrocytes, BMP-2 induces the expression of BMP-4 mRNA in a cell maturation-dependent manner [12].
Positive_regulation (induces) of Gene_expression (expression) of BMP-4 mRNA in chondrocytes
2) Confidence 0.18 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.08 Pain Relevance 0
Rat BMP-4 mRNA expression was weak in the BMP-2 and in the BMP-7 single-gene transfer groups.


Positive_regulation (weak) of Gene_expression (expression) of BMP-4 mRNA
3) Confidence 0.18 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.07 Pain Relevance 0
Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression

Background

Positive_regulation (induces) of Gene_expression (expression) of BMP-4
4) Confidence 0.16 Published 2006 Journal BMC Musculoskelet Disord Section Title Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0

General Comments

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