INT19606

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Context Info
Confidence 0.22
First Reported 1990
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.25
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ear1) cellular_component (Ear1) biological_process (Ear1)
nuclease activity (Ear1)
Anatomy Link Frequency
sputum 1
eosinophil 1
Ear1 (Mus musculus)
Pain Link Frequency Relevance Heat
fortral 1 89.36 High High
Morphine 1 87.20 High High
Opioid 1 76.88 Quite High
Inflammation 138 75.88 Quite High
antagonist 5 75.12 Quite High
Analgesic 1 75.00 Quite High
Versed 2 63.72 Quite High
peripheral neuropathy 1 52.36 Quite High
headache 4 50.92 Quite High
methotrexate 10 16.36 Low Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 216 99.52 Very High Very High Very High
Asthma 94 98.80 Very High Very High Very High
Unconsciousness 1 91.16 High High
Nicotine Addiction 24 82.96 Quite High
Bullous Skin Disease 75 82.24 Quite High
B-cell Lymphoma 2 80.16 Quite High
INFLAMMATION 150 75.88 Quite High
T-cell Lymphoma 1 59.92 Quite High
Hepatitis 2 53.24 Quite High
Hematuria 1 52.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The KCN injection decreased the contents of phosphocreatine (PCr), ATP and glucose and increased the contents of AMP and lactate, resulting in a 34% decrease in energy charge potential (ECP) and an increase in lactate/pyruvate (L/P) ratio.
Negative_regulation (decrease) of ECP
1) Confidence 0.22 Published 1990 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2077184 Disease Relevance 0.09 Pain Relevance 0.37
Because of the limited availability of ECP, its high cost, and the lack of controlled trials, ECP is limited for patients who have failed glucocorticoid and other immunosuppressive therapies.
Negative_regulation (limited) of ECP
2) Confidence 0.03 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936286 Disease Relevance 0.77 Pain Relevance 0.08
In patients with COPD, small but significant reductions in sputum levels of albumin and eosinophil cationic protein were observed.
Negative_regulation (reductions) of eosinophil cationic protein in eosinophil associated with pulmonary disease
3) Confidence 0.01 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.18 Pain Relevance 0.07
However, such treatment did reduce levels of albumin and eosinophil cationic protein in sputum samples obtained from patients with COPD (Grootendorst, Gauw, Benschop et al 2003).


Negative_regulation (reduce) of eosinophil cationic protein in sputum associated with pulmonary disease
4) Confidence 0.01 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.21 Pain Relevance 0.09

General Comments

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