INT19608

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Context Info
Confidence 0.18
First Reported 1990
Last Reported 1994
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.14
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CLPP) mitochondrion (CLPP)
Anatomy Link Frequency
epithelium 1
CLPP (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 1 98.32 Very High Very High Very High
bradykinin 1 97.80 Very High Very High Very High
c fibre 1 95.68 Very High Very High Very High
Kinase C 1 87.28 High High
Neuropeptide 1 69.92 Quite High
Inflammatory mediators 1 68.40 Quite High
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Respiratory Disease 1 74.48 Quite High
INFLAMMATION 1 68.40 Quite High
Asthma 1 29.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Airway epithelium contains the enzyme neutral endopeptidase which can degrade several peptides into inactive fragments, thus regulating the actions of tachykinins released from sensory C-fibers via axon reflex.
Neg (inactive) Protein_catabolism (degrade) of endopeptidase in epithelium associated with c fibre
1) Confidence 0.18 Published 1990 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 2077199 Disease Relevance 0.14 Pain Relevance 0.21
Endopeptidase 24.11 (EP 24.11; also called neutral endopeptidase, enkephalinase, CALLA, or CD10) and endopeptidase 24.15 (EP 24.15) are widely distributed neutral metalloendopeptidases that degrade a number of bioactive peptides including substance P, bradykinin, neurotensin, and chemotactic peptides.
Protein_catabolism (degrade) of endopeptidase associated with bradykinin and substance p
2) Confidence 0.14 Published 1994-1995 Journal Enzyme Protein Section Abstract Doc Link 8589801 Disease Relevance 0 Pain Relevance 0.10

General Comments

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