INT19609

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.54
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSIP1) nucleoplasm (PSIP1) nucleolus (PSIP1)
nucleus (PSIP1) DNA binding (PSIP1)
Anatomy Link Frequency
plasma 1
epithelium 1
PSIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Etanercept 4 99.72 Very High Very High Very High
antagonist 12 99.30 Very High Very High Very High
Adalimumab 6 98.56 Very High Very High Very High
Infliximab 8 97.44 Very High Very High Very High
spinal inflammation 31 96.08 Very High Very High Very High
Arthritis 34 95.76 Very High Very High Very High
rheumatoid arthritis 54 95.56 Very High Very High Very High
Inflammation 49 90.56 High High
Inflammatory mediators 3 85.44 High High
Neuropeptide 1 84.32 Quite High
Disease Link Frequency Relevance Heat
Cancer 26 98.56 Very High Very High Very High
Low Back Pain 33 96.08 Very High Very High Very High
Seronegative Spondarthritis 31 95.76 Very High Very High Very High
Rheumatoid Arthritis 54 95.56 Very High Very High Very High
Asthma 1 95.52 Very High Very High Very High
Disease 84 90.92 High High
INFLAMMATION 49 90.56 High High
Atherosclerosis 1 87.88 High High
Recurrence 2 87.68 High High
Malignant Neoplastic Disease 3 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Etanercept is a soluble dimeric p75 TNF-?
Positive_regulation (dimeric) of p75 associated with etanercept
1) Confidence 0.49 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 2.14 Pain Relevance 1.49
In addition, airway epithelium can modulate contraction of airway smooth muscle by generating epithelium-derived relaxing factor (EpDRF).
Positive_regulation (generating) of epithelium-derived relaxing factor in epithelium
2) Confidence 0.17 Published 1990 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 2077199 Disease Relevance 0.26 Pain Relevance 0.19
Neutrophil counts, IL-1 receptor antagonist and soluble TNF receptors p55 and p75 plasma levels were increased during drug administration.
Positive_regulation (increased) of p75 in plasma associated with antagonist
3) Confidence 0.05 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 0.81 Pain Relevance 0.13
Nevertheless these cells may acquire, with time, new properties, such as genetic instability inducing in fine cellular transformation leading to neoplasia and eventually tumour formation.
Positive_regulation (inducing) of in fine associated with cancer
4) Confidence 0.02 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.33 Pain Relevance 0.24

General Comments

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