INT196097

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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.18
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpc5) transmembrane transport (Trpc5)
Anatomy Link Frequency
neurite 1
tubules 1
Trpc5 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 100 90.48 High High
Hippocampus 4 87.00 High High
Neuronal excitability 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 2 62.04 Quite High
Cancer 2 59.12 Quite High
Sprains And Strains 34 22.88 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Coronary Heart Disease 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Subacute Sclerosing Panencephalitis 4 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
About 2-fold increase and 3-fold decrease in the expressions of PTCH1 and TRPC5, respectively, was observed upon AICD overexpression (Figure 1(a)).
Gene_expression (expressions) of TRPC5
1) Confidence 0.54 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2935165 Disease Relevance 0.06 Pain Relevance 0
Distal tubules were also positive for TRPC5 and 6 but the staining intensity was much weaker (Fig. 4B).
Gene_expression (positive) of TRPC5 in tubules
2) Confidence 0.52 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.10
A decrease in the expression of TRPC5 by AICD overexpression might affect neurite outgrowth.

4.

Gene_expression (expression) of TRPC5 in neurite
3) Confidence 0.42 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2935165 Disease Relevance 0.12 Pain Relevance 0
Cellular localization of TRPC3, TRPC5 and TRPC6 mRNAs
Gene_expression (mRNAs) of TRPC5
4) Confidence 0.23 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.16

General Comments

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