INT196105

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 21
Disease Relevance 3.03
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm7) plasma membrane (Trpm7) kinase activity (Trpm7)
transmembrane transport (Trpm7) cytoplasm (Trpm7)
Anatomy Link Frequency
neurons 6
cerebrum 1
brain 1
lung 1
central nervous system 1
Trpm7 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 42 97.96 Very High Very High Very High
Central nervous system 21 96.84 Very High Very High Very High
ischemia 70 95.52 Very High Very High Very High
TRP channel 350 92.00 High High
Potency 56 91.20 High High
Pain 21 86.92 High High
imagery 84 82.68 Quite High
antagonist 42 78.36 Quite High
Inflammation 14 77.52 Quite High
Hippocampus 28 28.48 Quite Low
Disease Link Frequency Relevance Heat
Death 35 98.24 Very High Very High Very High
Sprains And Strains 119 97.88 Very High Very High Very High
Cv Unclassified Under Development 42 95.52 Very High Very High Very High
Brain Hemorrhage 28 95.08 Very High Very High Very High
Epilepsy 42 94.32 High High
Stress 14 91.00 High High
Pain 21 86.92 High High
INFLAMMATION 14 77.52 Quite High
Coronary Heart Disease 14 5.00 Very Low Very Low Very Low
Subacute Sclerosing Panencephalitis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although, this result paralleled what was observed with over expression of TRPM7 channels, it occurred at a much higher concentration of extracellular divalent cations.


Gene_expression (expression) of TRPM7
1) Confidence 0.77 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.04
Lowering extracellular Ca2+ and Mg2+ also evokes a divalent-sensitive non-selective cation current that is mediated by TRPM7 expression in hippocampal neurons.
Gene_expression (expression) of TRPM7 in neurons
2) Confidence 0.77 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3022637 Disease Relevance 0.17 Pain Relevance 0.04
We also found that NM inhibited TRPM7 currents expressed in HEK293T cells in direct inverse relationship to the extracellular concentrations of Ca2+ and Mg2+.
Gene_expression (expressed) of TRPM7
3) Confidence 0.77 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.16 Pain Relevance 0.13
Here we report that a synthetic serine protease inhibitor, nafamostat mesylate (NM), and several of its analogues, block recombinant TRPM7 currents expressed in HEK293T cells in inverse relationship to the concentration of extracellular divalent cations.
Gene_expression (expressed) of recombinant TRPM7
4) Confidence 0.67 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3022637 Disease Relevance 0.19 Pain Relevance 0.05
M) inhibits TRPM7 current and pre-exposed HSB (200 ?
Gene_expression (current) of TRPM7
5) Confidence 0.67 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0
We were able to use this approach to show that reducing TRPM7 currents in CA1 neurons of the rat provides substantial protection against the loss of CA1 neurons in a model of global ischemia [5,7].
Gene_expression (currents) of TRPM7 in neurons associated with ischemia
6) Confidence 0.67 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.30 Pain Relevance 0.13
DAPI completely and reversibly blocked TRPM7 current with an IC50 of 38 ?
Gene_expression (current) of TRPM7
7) Confidence 0.67 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.03
Among the TRPMs, the chanzyme TRPM7 dominated over all other tested TRP members and seems to be ubiquitously expressed.
Gene_expression (expressed) of TRPM7
8) Confidence 0.63 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.07 Pain Relevance 0
In the mouse, the TRPM7 gene was consistently expressed in all tested organs and tissues and it was at the same time it was the dominating isoform except for brain areas.
Gene_expression (expressed) of TRPM7 gene in brain
9) Confidence 0.63 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0
Both the RNA message for TRPM7 and the protein itself are expressed in cultured hippocampal neurons as well as in CA1 pyramidal neurons of the rat [5,7].
Gene_expression (expressed) of TRPM7 in neurons associated with pyramidal cell
10) Confidence 0.60 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.32 Pain Relevance 0.11
One of these, the TRPM7 channel, is widely expressed in various locations throughout the body and, it is also expressed within the central nervous system.
Gene_expression (expressed) of TRPM7 in central nervous system associated with central nervous system
11) Confidence 0.60 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.16 Pain Relevance 0.09
NM analogues block TRPM7 currents in cultured hippocampal neurons
Gene_expression (currents) of TRPM7 in neurons
12) Confidence 0.58 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.07
NM and divalent cation block of recombinant TRPM7 channels in HEK293T cells
Gene_expression (channels) of recombinant TRPM7
13) Confidence 0.58 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.07
NM blocks TRPM7 currents in cultured Hippocampal Neurons
Gene_expression (currents) of TRPM7 in Neurons
14) Confidence 0.58 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.04
Reductions in the concentration of divalent cations dramatically enhance inward currents mediated by recombinant TRPM7 channels, expressed in cell lines as well as in hippocampal neurons [6,21,22].
Gene_expression (expressed) of recombinant TRPM7 in neurons
15) Confidence 0.52 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.07 Pain Relevance 0.03
NM is a blocker of recombinant TRPM7 currents expressed in HEK293T cells
Gene_expression (expressed) of recombinant TRPM7
16) Confidence 0.52 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.11
However, TRPC3, C6, TRPM7, M3, TRPV2 and V4 expression showed marked differences in the three tested mouse strains.
Gene_expression (expression) of TRPM7 associated with sprains and strains
17) Confidence 0.49 Published 2006 Journal BMC Genomics Section Abstract Doc Link PMC1557673 Disease Relevance 0.25 Pain Relevance 0.19
Furthermore, TRPM7 expression was very low in tissues of NOD mice compared to the C57Bl/10 and Balb/c strain (Fig. 5).


Gene_expression (expression) of TRPM7 associated with sprains and strains
18) Confidence 0.49 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.50 Pain Relevance 0.03
In lung and kidney TRPV4, TRPV5 and TRPM7 were found in highest levels.
Gene_expression (found) of TRPM7 in kidney
19) Confidence 0.49 Published 2006 Journal BMC Genomics Section Abstract Doc Link PMC1557673 Disease Relevance 0.16 Pain Relevance 0.15
The very high expression of TRPM3 and M7 in cerebrum of C57Bl/10 mice was not observed in NOD and Balb/c.
Gene_expression (expression) of M7 in cerebrum
20) Confidence 0.49 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.52 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox