INT196115

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.66
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npcd) biological_process (Npcd) cytoplasm (Npcd)
Npcd (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 100 100.00 Very High Very High Very High
Morphine 688 99.18 Very High Very High Very High
cocaine 4 88.48 High High
withdrawal 36 75.56 Quite High
Opioid 112 75.12 Quite High
Eae 28 73.68 Quite High
Neuropeptide 4 72.08 Quite High
Physical dependence 40 70.64 Quite High
Glutamate receptor 4 69.20 Quite High
narcan 20 68.88 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 362 99.92 Very High Very High Very High
Overactive Bladder 4 76.88 Quite High
Opiate Addiction 32 75.56 Quite High
Drug Dependence 48 70.64 Quite High
Nervous System Malformation 16 65.28 Quite High
Schizophrenia 4 59.84 Quite High
Shock 32 59.76 Quite High
Apoptosis 32 56.00 Quite High
Stress 12 5.00 Very Low Very Low Very Low
Decapitation 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified numerous novel morphine-regulated genes (for instance, Olig2 and Camk1g), and a number of transcripts with strain-specific changes in expression (for instance, Hspa1a and Fzd2).
Negative_regulation (number) of transcripts associated with sprains and strains and morphine
1) Confidence 0.02 Published 2007 Journal Genome Biol Section Abstract Doc Link PMC2394777 Disease Relevance 0.45 Pain Relevance 1.10
In comparison with acute morphine, repeated administration caused a large decrease in mRNA levels of many genes, including the over-represented group of histone transcripts involved in nucleosome assembly and chromatin remodeling.
Negative_regulation (decrease) of transcripts associated with morphine
2) Confidence 0.02 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.19 Pain Relevance 0.69
Furthermore, complex strain-specific and region-specific expression patterns of a number of transcripts were recently reported [19].
Negative_regulation (number) of transcripts associated with sprains and strains
3) Confidence 0.02 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.57 Pain Relevance 0.49
Transcripts for very-low-density lipoprotein receptor (Vldlr) and sterol-C5-desaturase (Sc5d) were downregulated.
Negative_regulation (downregulated) of Transcripts
4) Confidence 0.02 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.45 Pain Relevance 0.40
Copy numbers of individual TRP channel transcripts are given in relation to those of 18S cDNA.
Negative_regulation (numbers) of transcripts associated with trp channel
5) Confidence 0.01 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.19
Absolute copy numbers of TRP channel transcripts and 18S cDNA were determined using calibration curves generated with cloned PCR fragment standards.
Negative_regulation (numbers) of transcripts associated with trp channel
6) Confidence 0.01 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.20

General Comments

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