INT196144

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Context Info
Confidence 0.14
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Acp5) lysosome (Acp5)
Anatomy Link Frequency
macrophages 1
bone marrow 1
Acp5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 24 84.24 Quite High
rheumatoid arthritis 25 71.96 Quite High
Inflammation 18 70.92 Quite High
Arthritis 18 52.00 Quite High
antagonist 8 42.96 Quite Low
metalloproteinase 37 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 135 97.32 Very High Very High Very High
Osteoporosis 4 91.68 High High
Hypercalcemia 11 75.76 Quite High
Rheumatoid Arthritis 25 71.96 Quite High
INFLAMMATION 17 70.92 Quite High
Disease 9 56.64 Quite High
Arthritis 23 52.00 Quite High
Metastasis 62 50.00 Quite Low
Breast Cancer 40 50.00 Quite Low
Pressure And Volume Under Development 5 45.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histology and tartrate-resistant acid phosphatase staining
Negative_regulation (Histology) of Gene_expression (staining) of tartrate-resistant acid phosphatase
1) Confidence 0.14 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1557720 Disease Relevance 0.42 Pain Relevance 0
Mouse spleen cells and bone marrow macrophages express IL-4 and IL-13 receptors, and the addition of these factors decreased RANKL-stimulated tartrate-resistant acid phosphatase-positive multi-nucleated cell formation and cathepsin K message in spleno-cytes and bnone marrow macrophages [80].
Negative_regulation (decreased) of in macrophages Gene_expression (message) of tartrate-resistant acid phosphatase in bone marrow
2) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.59 Pain Relevance 0.26

General Comments

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