INT196155

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.38
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nrp1) cytosol (Nrp1) cell adhesion (Nrp1)
plasma membrane (Nrp1)
Anatomy Link Frequency
tail 1
Nrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 30 99.24 Very High Very High Very High
rheumatoid arthritis 58 82.24 Quite High
cytokine 4 74.32 Quite High
Nerve growth factor 49 60.56 Quite High
Antinociceptive 1 56.64 Quite High
Arthritis 8 50.00 Quite Low
Pain 2 46.00 Quite Low
qutenza 3 40.16 Quite Low
chemokine 4 31.52 Quite Low
Glutamate receptor 2 31.04 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 7 100.00 Very High Very High Very High
INFLAMMATION 31 99.24 Very High Very High Very High
Shock 28 99.04 Very High Very High Very High
Acanthosis 2 95.72 Very High Very High Very High
Eczema 108 91.28 High High
Hyperplasia 6 84.88 Quite High
Rheumatoid Arthritis 59 82.24 Quite High
Cancer 15 72.80 Quite High
Disease 19 66.04 Quite High
Ocular Toxicity (including Many Sub-types) 1 64.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, Sema3A and NRP-1 of its receptors expressed in human keratinocytes52 may be relevant to the above-mentioned suppressive effect of Sema3A on acanthosis observed in our present experiment.
NRP-1 Binding (receptors) of associated with acanthosis
1) Confidence 0.16 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.49 Pain Relevance 0.06
Third, NP-1 could hamper synoviocyte apoptosis upon ligation of VEGF165, and thus, function as a survival factor, in an autocrine or paracrine fashion.
NP-1 Binding (ligation) of associated with apoptosis
2) Confidence 0.10 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.65 Pain Relevance 0.64
In contrast, no binding was observed between NMDARs and the ectodomain of CSF-1 (Figure 4B, lane 6), or between NMDARs and the CUB domains of neuropilin-1 (Figure 4B, lane 7).
neuropilin-1 Neg (no) Binding (binding) of
3) Confidence 0.08 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
A complex of PlexinA1 and neuropilin 1 (NP1) was shown to act as a receptor for Sema3A [10,11].
neuropilin 1 Binding (complex) of
4) Confidence 0.08 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.19 Pain Relevance 0
Both the basic tail and the sema domain of Sema3A are important for binding to Npn-1, although binding to the sema domain is weaker.
Npn-1 Binding (binding) of in tail
5) Confidence 0.01 Published 2006 Journal Genome Biol Section Body Doc Link PMC1557745 Disease Relevance 0.05 Pain Relevance 0

General Comments

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