INT196181

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.64
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SEMA3A) extracellular region (SEMA3A)
Anatomy Link Frequency
tail 1
brain 1
SEMA3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 25 71.20 Quite High
backache 16 5.28 Low Low
Chronic low back pain 36 5.00 Very Low Very Low Very Low
Nerve growth factor 24 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Sciatica 4 5.00 Very Low Very Low Very Low
calcitonin gene related peptide 4 5.00 Very Low Very Low Very Low
substance P 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 6 86.24 High High
Hyperplasia 4 78.48 Quite High
Hypoxia 12 65.44 Quite High
Shock 13 51.32 Quite High
Metastasis 2 34.44 Quite Low
Low Back Pain 52 5.28 Low Low
Nociception 20 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
Intervertebral Disk Degeneration 12 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Positive controls included rat brain for sem3A, human tonsil for CD31 and human brain for PGP9.5.
sem3A Binding (brain) of in brain
1) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0
Sema3A and VEGF compete for overlapping binding sites on the NRPs and therefore competitively inhibit one another [52].
Sema3A Binding (compete) of
2) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.17 Pain Relevance 0.07
This suggests that sem3A may be secreted by a healthy disc cell and then bind to a NRP-1 molecule on the same cell or a neighbouring cell.
sem3A Binding (bind) of
3) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.16 Pain Relevance 0
For example, sema3A has a high affinity for NRP-1 and NRP-1 was expressed highly by the disc cells as well as PLXA3.
sema3A Binding (affinity) of
4) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.26 Pain Relevance 0
Both the basic tail and the sema domain of Sema3A are important for binding to Npn-1, although binding to the sema domain is weaker.
Sema3A Binding (binding) of in tail
5) Confidence 0.16 Published 2006 Journal Genome Biol Section Body Doc Link PMC1557745 Disease Relevance 0.05 Pain Relevance 0

General Comments

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