INT196182

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 3.61
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NRP2) cell adhesion (NRP2) plasma membrane (NRP2)
Anatomy Link Frequency
joints 1
endothelial cells 1
NRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 120 99.84 Very High Very High Very High
Osteoarthritis 6 95.92 Very High Very High Very High
dorsal root ganglion 2 91.60 High High
chemokine 10 83.48 Quite High
Inflammation 57 73.44 Quite High
Inflammatory mediators 4 51.76 Quite High
Arthritis 16 50.00 Quite Low
Inflammatory response 4 42.44 Quite Low
cytokine 10 34.96 Quite Low
calcitonin gene related peptide 2 30.08 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 122 99.84 Very High Very High Very High
Cancer 52 99.84 Very High Very High Very High
Hyperplasia 14 99.46 Very High Very High Very High
Osteoarthritis 6 95.92 Very High Very High Very High
Shock 37 95.40 Very High Very High Very High
Metastasis 18 93.52 High High
Ganglion Cysts 2 90.64 High High
Chronic Sinusitis 55 90.48 High High
Syndrome 11 85.60 High High
Fibromyalgia 2 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This family, Class 3 semaphorins (sema3), are a large subgroup of these polypeptides, containing members A-G, which are the only secreted form of semaphorins found in vertebrates.
Localization (secreted) of semaphorins
1) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.17 Pain Relevance 0.05
This family, Class 3 semaphorins (sema3), are a large subgroup of these polypeptides, containing members A-G, which are the only secreted form of semaphorins found in vertebrates.
Localization (secreted) of semaphorins
2) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.17 Pain Relevance 0.04
It should be noted that out of the 9 CRSwNP patients where no se could be detected, 1, 4 and 4 were observed in NP1, NP2 and NP3, respectively.
Spec (observed) Localization (observed) of NP2
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.77 Pain Relevance 0.08
and IL-6, in turn, further enhance the capacities of macrophages and synoviocytes to secrete VEGF165, and stimulate endothelial cells to induce cell-contact-mediated macrophage activation, which generates a positive feedback-loop (Figure 1).
Localization (secrete) of VEGF165 in endothelial cells
4) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.63 Pain Relevance 0.26
Moreover, hyperplastic synoviocytes in RA joints secrete more VEGF165, and thus, generate positive feedback that promotes their survival (Figure 1).

3.

Localization (secrete) of VEGF165 in joints associated with rheumatoid arthritis and hyperplasia
5) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.23 Pain Relevance 0.38
The semaphorins

Semaphorins are secreted, transmembrane, and GPI-linked proteins found in mammals, Drosophila, nematodes, and crustaceans.

Localization (secreted) of semaphorins
6) Confidence 0.01 Published 2006 Journal Genome Biol Section Title Doc Link PMC1557745 Disease Relevance 0.09 Pain Relevance 0
The semaphorins

Semaphorins are secreted, transmembrane, and GPI-linked proteins found in mammals, Drosophila, nematodes, and crustaceans.

Localization (secreted) of Semaphorins
7) Confidence 0.01 Published 2006 Journal Genome Biol Section Title Doc Link PMC1557745 Disease Relevance 0.09 Pain Relevance 0
What special attributes and abilities do the secreted, transmembrane, and GPI-linked forms of semaphorins functionally provide?
Localization (secreted) of semaphorins
8) Confidence 0.01 Published 2006 Journal Genome Biol Section Body Doc Link PMC1557745 Disease Relevance 0 Pain Relevance 0
Several secreted and transmembrane semaphorins undergo proteolytic processing, and this is important in semaphorin-mediated repulsive axon guidance, growth-cone collapse, cell migration, invasive growth, and metastasis (for example, see [32-35]).
Localization (secreted) of semaphorins associated with shock and metastasis
9) Confidence 0.01 Published 2006 Journal Genome Biol Section Body Doc Link PMC1557745 Disease Relevance 0.31 Pain Relevance 0
Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues.
Localization (secreted) of Semaphorins
10) Confidence 0.01 Published 2006 Journal Genome Biol Section Abstract Doc Link PMC1557745 Disease Relevance 0.10 Pain Relevance 0
Semaphorins vary in their membrane anchorage, and include secreted, transmembrane, and GPI-linked family members (Figure 2).
Localization (secreted) of Semaphorins
11) Confidence 0.01 Published 2006 Journal Genome Biol Section Body Doc Link PMC1557745 Disease Relevance 0.06 Pain Relevance 0

General Comments

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