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Context Info
Confidence 0.08
First Reported 1990
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.05
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SHMT2) methyltransferase activity (SHMT2)
Anatomy Link Frequency
brain 1
melanocyte 1
SHMT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
addiction 2 100.00 Very High Very High Very High
Serotonin 29 98.84 Very High Very High Very High
Glutamate 45 97.64 Very High Very High Very High
Migraine 67 96.56 Very High Very High Very High
Neurotransmitter 9 84.32 Quite High
excitatory amino acid 5 83.60 Quite High
Neuronal excitability 1 80.52 Quite High
hyperexcitability 2 76.12 Quite High
agonist 7 70.96 Quite High
Disease Link Frequency Relevance Heat
Poisoning 1 99.30 Very High Very High Very High
Headache 69 96.56 Very High Very High Very High
Injury 2 81.84 Quite High
Pigment Disorder 32 81.44 Quite High
Disease 4 81.04 Quite High
Epilepsy 2 67.88 Quite High
Cognitive Disorder 2 66.88 Quite High
Pain 13 51.36 Quite High
Headache Disorders 2 37.92 Quite Low
Syndrome 1 6.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, when completely inhibited by the organophosphorous poison diisopropylfluorophosphate (DFP), Gly-70 BuChE failed to be reactivated by 10 mM of the cholinesterase-specific oxime pyridine 2-aldoxime methiodide (2-PAM); a concentration restoring about 50% of activity in the "normal" Asp-70 recombinant enzyme.
Positive_regulation (reactivated) of Gly-70 associated with poisoning
1) Confidence 0.08 Published 1990 Journal J. Neurosci. Res. Section Abstract Doc Link 2079709 Disease Relevance 0.10 Pain Relevance 0
Monte Carlo simulation for Met-enkephalin (CHO-Tyr-Gly-Gly-Phe-Met-NH2) by using the SAAP force field revealed that the conformation in vacuo is mainly controlled by strong electrostatic interactions between the amino acid residues, while the SAAPs and the interamino acid Lennard-Jones potentials are predominant in water.
Positive_regulation (simulation) of CHO-Tyr-Gly-Gly-Phe-Met-NH2 associated with enkephalin
2) Confidence 0.06 Published 2009 Journal J Comput Chem Section Abstract Doc Link 19140140 Disease Relevance 0 Pain Relevance 0.10
Previously we have shown that the Na+-dependence of Gly–Sar uptake can be attributed to a lack of NHE3 activity in the absence of extracellular Na+ [10,12,18].
Positive_regulation (dependence) of Gly associated with addiction
3) Confidence 0.05 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2428106 Disease Relevance 0 Pain Relevance 0.05
GLY-GLY motifs increase instability of the collagen triple helix,33 resulting in extra flexibility.
Positive_regulation (increase) of GLY-GLY
4) Confidence 0.04 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0.04
In addition, cerebrospinal fluid (CSF) Gln, Gly and taurine (Tau) concentrations are elevated in migraineurs [30] suggesting glutamatergic systems are likely to be altered in the migraine brain.
Positive_regulation (elevated) of Gly in brain associated with migraine
5) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714306 Disease Relevance 0.87 Pain Relevance 1.09
Chloride influx (induced by activation of GlyCl and demonstrated directly using ion chromatography analysis) induces an increase in melanocyte number.
Positive_regulation (activation) of GlyCl in melanocyte
6) Confidence 0.00 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

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