INT19621

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 23
Total Number 31
Disease Relevance 14.00
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD86) cell-cell signaling (CD86)
Anatomy Link Frequency
CD86 22
plasma 2
T-cell 2
PDL-1 1
blood 1
CD86 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 134 100.00 Very High Very High Very High
abatacept 23 99.36 Very High Very High Very High
Inflammation 484 97.84 Very High Very High Very High
rheumatoid arthritis 59 97.12 Very High Very High Very High
methotrexate 3 95.28 Very High Very High Very High
Multiple sclerosis 2 92.48 High High
cytokine 85 87.80 High High
Neuritis 2 85.92 High High
Infliximab 13 74.36 Quite High
cINOD 38 50.92 Quite High
Disease Link Frequency Relevance Heat
Photosensitivity Disorders 63 99.48 Very High Very High Very High
Poisoning 1 99.16 Very High Very High Very High
Infection 183 98.72 Very High Very High Very High
Adenocarcinoma 990 98.68 Very High Very High Very High
Phototoxic Dermatitis 84 97.88 Very High Very High Very High
INFLAMMATION 529 97.84 Very High Very High Very High
Rheumatoid Arthritis 59 97.12 Very High Very High Very High
Chlamydia Infection 88 94.96 High High
Disease 117 93.52 High High
Demyelinating Disease 2 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD86 induction was thus perceived as a suitable endpoint for photoallergen detection.
Positive_regulation (induction) of CD86 in CD86
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.07 Pain Relevance 0
Here, non-irradiated 6-MC also resulted in a relevant CD86 induction indicating an allergenic potential consistent with Buehler et al. [33] who considered 6-MC as contact allergen with weak phototoxic potential.
Positive_regulation (induction) of CD86 in CD86
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.30 Pain Relevance 0
Since CD86 was markedly upregulated in response to irradiated CPZ (in contrast to CD83 and HLA-DR), it was chosen as the sole marker for the analysis of the following experiments.
Positive_regulation (upregulated) of CD86 in CD86
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.09 Pain Relevance 0
After 7 days of cultivation in vitro, the cells turned into DCs, as indicated by the loss of CD14 receptors and the upregulation of HLA-DR, CD80 and CD86 receptors (data not shown).
Positive_regulation (upregulation) of CD86 in CD86
4) Confidence 0.67 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.98 Pain Relevance 0.10
The myeloid dendritic cells in CSF expressed higher levels of HLA-DR, CD86, CD80 and CD40 than those in blood, whereas expression of these molecules by plasmacytoid dendritic cells was equal in blood and CSF.
Positive_regulation (levels) of CD86 in blood
5) Confidence 0.56 Published 2001 Journal Brain Section Abstract Doc Link 11222448 Disease Relevance 1.00 Pain Relevance 0.43
In another study, we could demonstrate that the presence of 33% dead cells induced the unspecific upregulation of the CD86 expression [18].
Positive_regulation (upregulation) of CD86 in CD86
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.07 Pain Relevance 0
HCA demonstrated a very similar and dose-dependent CD86 induction with and without irradiation and we thus concluded that HCA has no photoallergenic but an allergenic potential.
Positive_regulation (induction) of CD86 in CD86
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.11 Pain Relevance 0.05
CD86 values induced by the photoallergens after irradiation were always more than 15% higher than the corresponding values obtained without irradiation.
Positive_regulation (induced) of CD86 in CD86
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.10 Pain Relevance 0
The expression of co-stimulating factor CD86 (B7-2) on the surface of DC was detected by flow cytometry, and the stimulating capacity of DC was determined by mixed lymphocyte reaction (MLR).
Positive_regulation (co-stimulating) of B7-2 in CD86
9) Confidence 0.49 Published 2005 Journal Chin J Integr Med Section Body Doc Link 16417775 Disease Relevance 0.16 Pain Relevance 0
Dose-dependent increases in CD86 and HLA-DR (but not CD83) expression were observed at radiation doses >1 J/cm2 UVA.
Positive_regulation (increases) of CD86 in CD86
10) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.27 Pain Relevance 0
The CD83, CD40 and CD86 are upregulated as a step in the maturation process and have a role in immune modulation [38].
Positive_regulation (upregulated) of CD86 in CD86
11) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.15 Pain Relevance 0.15
The combined plasma induced upregulation of CD40 (median 118, median 98), and CD86, (median 105, median 112), in both MDCs and PDCs.
Positive_regulation (upregulation) of CD86 in plasma
12) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.57 Pain Relevance 0.03
CD83 is a glycoprotein that is upregulated together with costimulatory molecules, such as CD40 and CD86, thus suggesting a role in the induction of immune responses [38].
Positive_regulation (upregulated) of CD86 in CD86
13) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.85 Pain Relevance 0.04
In addition to its effects on airway neutrophilia, we have recently reported that O3 challenge (0.4 ppm, 2 hr) causes an increase in expression of cell-surface phenotypes CD11b, mCD14, CD16, CD86, and HLA-DR on sputum monocytes recovered from normal volunteers (Alexis et al. 2004a).
Positive_regulation (phenotypes) of CD86 in CD86
14) Confidence 0.25 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.17 Pain Relevance 0
Mature DCs express high levels of Class I and Class II molecules, altered chemokine and galectin family (Dietz et al 2000; Bax et al 2007) expression, co-stimulatory markers CD80 and CD86, and the immunoglobulin CD83 (Zhou and Tedder 1995).
Positive_regulation (markers) of CD86 in CD86 associated with chemokine
15) Confidence 0.22 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727883 Disease Relevance 0.29 Pain Relevance 0.09
In normal immunologic responses, TLR activation of monocytes and DCs results in activation of costimulatory molecules CD80 and CD86.
Positive_regulation (activation) of CD86 in monocytes
16) Confidence 0.22 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.44 Pain Relevance 0.04
The TLR9 ligation on PDCs induced a mature phenotype with upregulation of CD40, CD83, CD86, CCR7, PDL-1, ICOSL and CCR5 and decreased B7H3 and DCIR (Figure 9).
Positive_regulation (upregulation) of CD86 in PDL-1
17) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.30 Pain Relevance 0.03
Abatacept selectively modulates the CD80/CD86:CD28 co-stimulatory signal required for full T-cell activation, and has been approved for the treatment of rheumatoid arthritis (RA) in combination with methotrexate in a number of countries, including the United States, Canada, and the European Union.
Positive_regulation (required) of CD86 in T-cell associated with rheumatoid arthritis, abatacept and methotrexate
18) Confidence 0.21 Published 2007 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 17977488 Disease Relevance 0.38 Pain Relevance 0.53
Abatacept is a recombinant soluble fusion protein that inhibits the CD80/CD86:CD28 costimulatory signal required for T cell activation and has demonstrated efficacy in the treatment of rheumatoid arthritis.
Positive_regulation (required) of CD86 in T cell associated with rheumatoid arthritis and abatacept
19) Confidence 0.21 Published 2007 Journal J Clin Pharmacol Section Abstract Doc Link 17962428 Disease Relevance 0.34 Pain Relevance 0.39
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Positive_regulation (increased) of CD86 in CD86
20) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.60 Pain Relevance 0.03

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