INT196216

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CACNA1A, REST) nucleus (CACNA1A, REST) small molecule metabolic process (CACNA1A)
intracellular (REST) DNA binding (REST) transmembrane transport (CACNA1A)
Anatomy Link Frequency
HeLa 2
CACNA1A (Homo sapiens)
REST (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 22 26.24 Quite Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 49.24 Quite Low
Disease 8 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 2 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Cerebellar Diseases 2 5.00 Very Low Very Low Very Low
Nervous System Malformation 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Headache 2 5.00 Very Low Very Low Very Low
Ataxia 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore REST is only recruited to the high-affinity RE1s of the CACNA1A gene in HeLa cells under normal conditions, but weaker RE1s retain the ability to specifically recruit REST at elevated concentrations.
CACNA1A Binding (recruit) of REST in HeLa
1) Confidence 0.28 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0 Pain Relevance 0
We assayed REST occupancy at the four functional CACNA1A RE1s in HeLa by ChIP assay.
CACNA1A Binding (occupancy) of REST in HeLa
2) Confidence 0.28 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0 Pain Relevance 0

General Comments

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