INT196229

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CACNA1A) cell death (CACNA1A) plasma membrane (CACNA1A)
nucleus (CACNA1A) transmembrane transport (CACNA1A) cytoplasm (CACNA1A)
Anatomy Link Frequency
HeLa 1
brain 1
CACNA1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 22 76.84 Quite High
Neurotransmitter 10 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 99.92 Very High Very High Very High
Anaplastic Astrocytoma 2 63.52 Quite High
Disease 8 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Cerebellar Diseases 2 5.00 Very Low Very Low Very Low
Nervous System Malformation 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Headache 2 5.00 Very Low Very Low Very Low
Ataxia 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, variation in REST protein levels through organs such as the brain might lead to finely patterned levels of CACNA1A transcription (58).
Transcription (transcription) of CACNA1A in brain
1) Confidence 0.60 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.14 Pain Relevance 0
Virally mediated overexpression of a dominant-negative REST construct resulted in 75-fold de-repression of CACNA1A mRNA levels in HeLa cells (Figure 4A), indicating that REST is capable of strongly repressing this gene.
Transcription (levels) of CACNA1A in HeLa associated with repression
2) Confidence 0.44 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.10 Pain Relevance 0.07

General Comments

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