INT196247

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.76
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
nerve 2
synapse 2
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 5 100.00 Very High Very High Very High
Botox 10 96.30 Very High Very High Very High
Calcium channel 11 82.88 Quite High
hyperexcitability 1 80.24 Quite High
Pain 2 67.60 Quite High
Neuropeptide 1 45.28 Quite Low
Migraine 1 29.20 Quite Low
alcohol 1 6.16 Low Low
withdrawal 7 5.00 Very Low Very Low Very Low
intrathecal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Clostridium Infection 1 91.64 High High
Spasticity 27 89.20 High High
Syndrome 1 83.44 Quite High
Sleep Disorders 2 80.72 Quite High
Cognitive Disorder 2 79.76 Quite High
Pain 2 67.60 Quite High
Stroke 11 50.00 Quite Low
Disease 4 45.84 Quite Low
Contracture 2 39.20 Quite Low
Cerebellar Diseases 1 31.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
REST's target genes include many necessary for terminally differentiated neuronal function, such as synapse formation (SYN1) (28), neurotransmitter secretion (SNAP25) (26) and signalling (CHRM4) (29).
Negative_regulation (include) of Localization (secretion) of SNAP25 in synapse associated with neurotransmitter
1) Confidence 0.29 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0 Pain Relevance 0.13
Botulinum toxin type A binds to the receptors in the presynaptic, cholinergic motor nerve terminal and is taken up by the nerve cells where the light chain of toxin cleaves a synaptosome-associated protein (SNAP-25) to inhibit acetylcholine release from the nerve terminal.
Negative_regulation (inhibit) of Localization (release) of SNAP-25 in nerve associated with botox
2) Confidence 0.03 Published 2010 Journal J Neurol Section Body Doc Link PMC2910313 Disease Relevance 0.76 Pain Relevance 0.24

General Comments

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