INT196248

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.15
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (REST) nucleolus (REST) nucleus (REST)
intracellular (REST) DNA binding (REST) transcription factor binding (REST)
REST (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 33 84.08 Quite High
Neurotransmitter 15 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
Migraine 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Astrocytoma 3 84.96 Quite High
Repression 9 68.72 Quite High
Disease 12 5.00 Very Low Very Low Very Low
Epilepsy 3 5.00 Very Low Very Low Very Low
Cerebellar Diseases 3 5.00 Very Low Very Low Very Low
Nervous System Malformation 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Headache 3 5.00 Very Low Very Low Very Low
Ataxia 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The three non-conserved human RE1s we tested by ChIP (CACNB2, CACNA1G, CACNG7) recruit REST in vivo, suggesting that these are functional sites (Figure 5D).
Localization (recruit) of REST
1) Confidence 0.66 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0 Pain Relevance 0.08
We identified a significant population of duplicated RE1s, principally but not exclusively associated with TEs, which are capable of recruiting REST and have been inserted throughout the human genome.
Localization (recruiting) of REST
2) Confidence 0.58 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0 Pain Relevance 0
In a similar way, the existence of closely spaced tandem RE1 clusters strongly suggests that this arrangement of sites has biological relevance, perhaps through their ability to recruit REST at low concentrations, or by simultaneous recruitment of multiple REST complexes at once to a target gene.
Localization (recruitment) of REST
3) Confidence 0.58 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox