INT196255

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMRN1) cell adhesion (MMRN1)
Anatomy Link Frequency
spine 2
ECM 2
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 15 93.32 High High
metalloproteinase 4 86.84 High High
cINOD 13 79.56 Quite High
cytokine 11 78.12 Quite High
Inflammation 36 77.76 Quite High
dexamethasone 28 76.96 Quite High
epidural 1 9.44 Low Low
backache 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 40 99.44 Very High Very High Very High
Death 14 98.48 Very High Very High Very High
Arthritis 4 98.12 Very High Very High Very High
Pancreatic Cancer 48 95.16 Very High Very High Very High
Cv General 4 Under Development 3 93.32 High High
INFLAMMATION 45 77.76 Quite High
Alzheimer's Dementia 18 69.68 Quite High
Cerebral Amyloid Angiopathy 32 63.92 Quite High
Targeted Disruption 2 58.92 Quite High
Hemorrhage 11 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeted therapy against FAK by methods such as using specific phosphorylation inhibitors could potentially be used to inhibit the cell-ECM interaction and thus suppress CAM-DR.
Negative_regulation (inhibit) of ECM Binding (interaction) of
1) Confidence 0.04 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.34 Pain Relevance 0
Moreover, it retains its mitogenic capacity in spine tissues while decreasing ECM formation, leading to clustering of cells often seen in arthritic states.
Negative_regulation (decreasing) of ECM Binding (formation) of in spine associated with arthritis
2) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453768 Disease Relevance 0.10 Pain Relevance 0.04
In addition to a direct loss of vessel wall integrity, MMP-2 mediated degradation of ECM components may lead to loss of specific ECM-integrin interactions resulting in apoptotic vascular cell death [40].
Negative_regulation (loss) of ECM-integrin Binding (interactions) of in ECM associated with apoptosis and death
3) Confidence 0.01 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1557842 Disease Relevance 1.14 Pain Relevance 0.48

General Comments

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