INT19626

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Context Info
Confidence 0.22
First Reported 1990
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 4
Total Number 8
Disease Relevance 2.69
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xdh) oxidoreductase activity (Xdh) extracellular region (Xdh)
peroxisome (Xdh) cytoplasm (Xdh)
Anatomy Link Frequency
muscle 2
blood 1
skeletal muscle 1
Xdh (Mus musculus)
Pain Link Frequency Relevance Heat
Endep 2 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
adenocard 4 99.88 Very High Very High Very High
Fibrositis 22 98.84 Very High Very High Very High
ischemia 3 93.00 High High
Osteoarthritis 3 91.72 High High
depression 7 87.84 High High
COX-2 inhibitor 1 81.24 Quite High
anesthesia 10 81.20 Quite High
Disease Link Frequency Relevance Heat
Gallstones 2 99.72 Very High Very High Very High
Toxicity 2 99.52 Very High Very High Very High
Sleep Disorders 16 98.84 Very High Very High Very High
Cv Unclassified Under Development 3 93.00 High High
Knee Osteoarthritis 2 91.72 High High
Stress 11 90.32 High High
Depression 7 87.84 High High
INFLAMMATION 1 75.52 Quite High
Osteoarthritis 1 71.68 Quite High
Pain 5 69.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Celecoxib-treated patients had significant decrease in nitrite levels (p = 0.043), whereas SOD, XO, GSH-Px enzyme activities, and MDA levels did not change significantly compared to baseline.
Neg (not) Regulation (change) of XO
1) Confidence 0.22 Published 2005 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15943176 Disease Relevance 0.57 Pain Relevance 0.49
Multiple free radical-generating pathways have been reported in skeletal muscle (22), and the present data argue that the XO pathway is important in superoxide formation in the extracellular fluid after a nondamaging protocol of muscle contractions in addition to the acknowledged activity of XO during and after tissue ischemia.


Regulation (important) of XO in skeletal muscle associated with ischemia
2) Confidence 0.19 Published 2010 Journal American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Section Body Doc Link PMC2806206 Disease Relevance 0.18 Pain Relevance 0.05
Hence, our data support the theory that XO is involved in superoxide radical release into the extracellular fluid during a nondamaging protocol of muscle contractions.
Regulation (involved) of XO in muscle
3) Confidence 0.19 Published 2010 Journal American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Section Body Doc Link PMC2806206 Disease Relevance 0.07 Pain Relevance 0
It appeared feasible that the effect of oxypurinol to reduce muscle force generation may have been responsible for the reduced superoxide release, rather than any direct effect of oxypurinol on XO activity reducing superoxide release.
Regulation (effect) of XO in muscle
4) Confidence 0.11 Published 2010 Journal American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Section Body Doc Link PMC2806206 Disease Relevance 0.21 Pain Relevance 0.04
The effect of amitriptyline (A, 20 mg daily) and sertraline (S, 100 mg daily) treatment on patients' superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (ADA) enzyme activities, thiobarbituric acid reactive substances (TBARS) and NO levels was investigated.
Spec (investigated) Regulation (effect) of XO associated with adenocard and endep
5) Confidence 0.11 Published 2006 Journal Rheumatol. Int. Section Abstract Doc Link 16283318 Disease Relevance 0.67 Pain Relevance 0.43
The effect of amitriptyline (A, 20 mg daily) and sertraline (S, 100 mg daily) treatment on patients' superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (ADA) enzyme activities, thiobarbituric acid reactive substances (TBARS) and NO levels was investigated.
Spec (investigated) Regulation (effect) of xanthine oxidase associated with adenocard and endep
6) Confidence 0.11 Published 2006 Journal Rheumatol. Int. Section Abstract Doc Link 16283318 Disease Relevance 0.66 Pain Relevance 0.43
Experiments were conducted on 182 rats with acute cholestasis to study the effect of intra-abdominal dalargin injection (10 mcg/kg) with the serotonin antagonist ketanserine (150 mg/kg) on xanthine oxidase (XO) activity and level of lipid peroxidation in the hepatic tissue and on the activity of the hepatospecific enzymes histidase and urokaninase in hepatic tissue and blood serum 1, 3, and 5 hours after the injection.
Regulation (effect) of XO in blood associated with antagonist, gallstones and serotonin
7) Confidence 0.07 Published 1990 Journal Patol Fiziol Eksp Ter Section Abstract Doc Link 2080086 Disease Relevance 0.17 Pain Relevance 0.10
In conclusion, erdosteine seems to be an alternative agent for protection of cardiac tissue against DXR-induced cardio-toxicity through its regulatory effect on XO activity and NO level.
Regulation (effect) of XO associated with toxicity
8) Confidence 0.03 Published 2003 Journal Toxicology Section Abstract Doc Link 12965118 Disease Relevance 0.17 Pain Relevance 0.15

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