INT196276

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1) signal transduction (PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
neurons 2
platelet 2
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 40 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
nMDA receptor 4 97.52 Very High Very High Very High
agonist 362 96.96 Very High Very High Very High
central sensitization 37 95.08 Very High Very High Very High
qutenza 64 91.92 High High
Spinal cord 15 71.96 Quite High
Dorsal horn 7 71.20 Quite High
bradykinin 4 57.52 Quite High
b2 receptor 4 45.68 Quite Low
Disease Link Frequency Relevance Heat
Pain 1 32.40 Quite Low
Increased Venous Pressure Under Development 14 32.36 Quite Low
Adhesions 4 25.12 Quite Low
Atherosclerosis 6 17.00 Low Low
Hypertension 16 15.40 Low Low
Thrombosis 14 14.84 Low Low
Nociception 24 10.16 Low Low
Stress 14 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is noteworthy that Ser329 has previously been identified as a target residue for PKA phosphorylation [33] while Ser331 was identified as a target for PKG phosphorylation [35] and Thr337 as a target for PKC phosphorylation [32].
Regulation (target) of Phosphorylation (phosphorylation) of PKG
1) Confidence 0.27 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
is not a direct target for either PKA or PKG phosphorylation or inhibition, but its RhoA-mediated signaling would be sensitive to RhoA phosphorylation by either second messenger kinase.
Regulation (target) of Phosphorylation (phosphorylation) of PKG
2) Confidence 0.21 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
, is also desensitized by the platelet antagonist /vasodilator nitric oxide (NO), involving direct NO/cGMP-dependent PKG phosphorylation of TP?
Regulation (desensitized) of Phosphorylation (phosphorylation) of PKG in platelet associated with antagonist
3) Confidence 0.21 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
-regulated PKC activation and phosphorylation of Ser145 and Thr337 and another involving eNOS phosphorylation and activation leading the NO/cGMP-regulated PKG phosphorylation of Ser331.
Regulation (regulated) of Phosphorylation (phosphorylation) of PKG
4) Confidence 0.20 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.17
-regulated PKC activation and phosphorylation of Ser145 and Thr337 and another involving eNOS phosphorylation and activation leading the NO/cGMP-regulated PKG phosphorylation of Ser331.
Regulation (regulated) of Phosphorylation (phosphorylation) of PKG
5) Confidence 0.20 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.16
is indeed a direct target of NO/PKG phosphorylation and heterologous desensitization [35].
Regulation (target) of Phosphorylation (phosphorylation) of PKG
6) Confidence 0.12 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.10
It is known that several protein kinases, such as PKC, PKA, PKG, MAPK and CaMKII, affect the responses of dorsal horn neurons through phosphorylation of synaptic receptors and proteins involved in the intracellular signal transduction pathways, and the consequences of this modulation could be central sensitization, long-lasting inhibition, and/or changes in gene expression [23-31,53,54].
Regulation (affect) of Phosphorylation (phosphorylation) of PKG in neurons associated with central sensitization and dorsal horn neuron
7) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1559591 Disease Relevance 0 Pain Relevance 0.54

General Comments

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