INT19628

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.90
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xdh) oxidoreductase activity (Xdh) extracellular region (Xdh)
peroxisome (Xdh) cytoplasm (Xdh)
Anatomy Link Frequency
brain 2
blood 1
Xdh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
anesthesia 3 94.92 High High
diclofenac 5 93.68 High High
ischemia 2 86.80 High High
Paracetamol 4 83.84 Quite High
alcohol 11 81.12 Quite High
Inflammation 16 75.00 Quite High
cINOD 2 69.64 Quite High
Analgesic 1 62.72 Quite High
Disease Link Frequency Relevance Heat
Decapitation 4 99.72 Very High Very High Very High
Gallstones 2 99.72 Very High Very High Very High
Stress 57 93.12 High High
Cv Unclassified Under Development 2 86.80 High High
Hypoxia 4 86.64 High High
Frostbite 1 86.32 High High
Poisoning 18 85.36 High High
Alcohol Intoxication 2 81.12 Quite High
Radiation Pneumonitis 1 81.00 Quite High
INFLAMMATION 17 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Xanthine oxidoreductase activity in rat brain tissue: the changes after decapitation].
Regulation (changes) of Xanthine oxidoreductase in brain associated with decapitation
1) Confidence 0.45 Published 1989 Journal No To Shinkei Section Title Doc Link 2803824 Disease Relevance 0.52 Pain Relevance 0.14
Effect of Dalargin (40 micrograms/kg) on xanthine-oxidase (X) activity in experimental Arduan-induced myoplegia (0.1 mg/kg) was studied in the brain tissue of 70 rats under inhalation anesthesia and artificial ventilation.
Regulation (Effect) of xanthine-oxidase in brain associated with anesthesia
2) Confidence 0.27 Published 1990 Journal Biull Eksp Biol Med Section Abstract Doc Link 2159814 Disease Relevance 0 Pain Relevance 0.09
Experiments were conducted on 182 rats with acute cholestasis to study the effect of intra-abdominal dalargin injection (10 mcg/kg) with the serotonin antagonist ketanserine (150 mg/kg) on xanthine oxidase (XO) activity and level of lipid peroxidation in the hepatic tissue and on the activity of the hepatospecific enzymes histidase and urokaninase in hepatic tissue and blood serum 1, 3, and 5 hours after the injection.
Regulation (effect) of xanthine oxidase in blood associated with antagonist, gallstones and serotonin
3) Confidence 0.26 Published 1990 Journal Patol Fiziol Eksp Ter Section Abstract Doc Link 2080086 Disease Relevance 0.17 Pain Relevance 0.10
None of treatments induced changes in xanthine oxidase activity, an index of ischemic condition.
Regulation (changes) of xanthine oxidase
4) Confidence 0.12 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12064817 Disease Relevance 0.20 Pain Relevance 0.70
A decrease in the NAD/NADH ratio causes conversion of xanthine dehydrogenase into xanthine oxidase, the cytosolic enzyme responsible for superoxide radical generation (Kato et al. 1990).
Regulation (responsible) of xanthine oxidase
5) Confidence 0.04 Published 2008 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2729157 Disease Relevance 0.17 Pain Relevance 0.04
Although the precise mechanisms involved are not known at present, possibilities include reduced levels of the antioxidant vitamins C and E [90,91], differential regulation of the xanthine oxidoreductase system [92] and/or aberrant arachidonic acid metabolism [93].
Regulation (regulation) of xanthine oxidoreductase
6) Confidence 0.01 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.83 Pain Relevance 0

General Comments

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