INT1963

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Context Info
Confidence 0.11
First Reported 1978
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 12
Total Number 39
Disease Relevance 3.73
Pain Relevance 7.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spikes 6
internal 3
platelet 2
dendrites 1
dendritic cell 1
Adp (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 14 100.00 Very High Very High Very High
antagonist 235 99.76 Very High Very High Very High
Action potential 598 99.60 Very High Very High Very High
agonist 126 99.34 Very High Very High Very High
Pyramidal cell 405 98.96 Very High Very High Very High
Angina 7 98.44 Very High Very High Very High
cytokine 74 98.28 Very High Very High Very High
addiction 216 98.00 Very High Very High Very High
adenocard 68 97.28 Very High Very High Very High
Calcium channel 378 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 18 100.00 Very High Very High Very High
Targeted Disruption 200 99.08 Very High Very High Very High
Cv General 3 Under Development 7 98.44 Very High Very High Very High
Coronary Artery Disease 2 91.52 High High
Nociception 62 91.32 High High
Increased Venous Pressure Under Development 16 90.16 High High
Disease 69 88.12 High High
Coronary Heart Disease 2 82.16 Quite High
Contracture 1 80.16 Quite High
INFLAMMATION 87 80.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Application of MRS2179 increased both the magnitude and duration of ADP-evoked inhibition of depolarizing responses (Figure 4).
Positive_regulation (increased) of ADP
1) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.19 Pain Relevance 0.51
Indeed, the inhibitory action of ADP in isolated neurons and on pain behavior in vivo was enhanced in the absence of P2Y1 signaling, suggesting an action of P2Y12 and/or P2Y13.
Positive_regulation (enhanced) of ADP in neurons associated with pain
2) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.41 Pain Relevance 0.55
Total and released ADP was decreased from 2.69 to 1.66, and from 1.90 to 1.21 respectively, and the total ATP/ADP ratio was increased from 1.85 to 2.84 (P less than 0.001).
Positive_regulation (increased) of ADP
3) Confidence 0.09 Published 1989 Journal Am. J. Hematol. Section Abstract Doc Link 2741922 Disease Relevance 0.33 Pain Relevance 0.13
Total and released ADP was decreased to 1.97 and 1.31 respectively, and the ATP/ADP ratio was increased to 2.38.
Positive_regulation (increased) of ADP
4) Confidence 0.09 Published 1989 Journal Am. J. Hematol. Section Abstract Doc Link 2741922 Disease Relevance 0.23 Pain Relevance 0.16
For example, Ca2+ entry and release from internal stores could activate nonselective cation currents, such as ICAN, which mediate the medium ADP.
Positive_regulation (mediate) of ADP in internal
5) Confidence 0.06 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.10
The medium ADP required action potential firing, although calcium spikes also activated the medium ADP in DHPG.
Positive_regulation (activated) of ADP in spikes associated with action potential
6) Confidence 0.06 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0.07 Pain Relevance 0.18
Blocking Ca2+ release from internal stores with cyclopiazonic acid (CPA; 20 µM) also reduced the medium ADP (Figure S6), suggesting that this is another important mechanism for induction of the medium ADP.
Positive_regulation (induction) of ADP in CPA
7) Confidence 0.06 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.11
These effects may also contribute somewhat to the medium ADP, as DHPG induced a small medium ADP even at very negative holding potentials, where activation of VGCCs is limited.
Positive_regulation (induced) of ADP
8) Confidence 0.06 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.03
Bath application of DHPG increased the fast ADP following a single spike, and the size of the medium ADP increased with both the number and the frequency of action potentials, reaching medium ADP values of nearly 15 mV for 5 spikes at 100 Hz (Figure S3).
Positive_regulation (increased) of ADP in spikes associated with action potential
9) Confidence 0.06 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.15
CP shows a small variation, ATP decreases to 60% and ADP + AMP increase for the same amount under FDNB during the development of a slight inhibition of contractility and a continuously growing inhibition and retardation of relaxation until systolic arrest.
Positive_regulation (increase) of ADP
10) Confidence 0.06 Published 1978 Journal Acta Biol. Med. Ger. Section Abstract Doc Link 310611 Disease Relevance 0.08 Pain Relevance 0.06
Patients with high adrenergic activity have significantly increased baseline ADP- and collagen-induced platelet aggregation.
Positive_regulation (increased) of ADP in platelet
11) Confidence 0.05 Published 2008 Journal Thromb. Haemost. Section Abstract Doc Link 18989527 Disease Relevance 0.22 Pain Relevance 0.13
We refer to this ADP as a medium ADP to distinguish it from the fast ADP following a single spike in normal ACSF [19]–[23] and a slow DHPG-induced ADP described later in this article.
Positive_regulation (induced) of ADP in spike
12) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.19
This medium-duration ADP is rapidly and reversibly induced by activation of mGluR5 and requires activation of phospholipase C (PLC) and release of calcium from internal stores.
Positive_regulation (requires) of ADP in internal
13) Confidence 0.05 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.43
None of these drugs blocked the slow ADP, however, suggesting further that distinct signaling mechanisms mediate the DHPG-induced medium ADP and slow ADP.


Positive_regulation (induced) of ADP
14) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.13
To determine the subcellular localization of the mGluRs mediating the medium ADP, DHPG was applied locally, by pressure application from a large patch pipette, to either the perisomatic region or the apical dendrites (see Materials and Methods for details).
Positive_regulation (mediating) of ADP in dendrites
15) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.12
All of these drugs inhibited the medium ADP, suggesting the Ca2+ release is required for the medium ADP, but not the slow ADP.
Positive_regulation (required) of ADP
16) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.14
Application of DHPG (or quisqualate, another group I mGluR agonist, Figure S1) eliminated the AHP, resulting in a post-burst ADP (+18.7±0.7 mV) that reached a peak at 34±3 ms after the last spike and decayed to 25% of the peak value in 200±23 ms (n?
Positive_regulation (resulting) of ADP in spike associated with agonist
17) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.22
To determine which group I mGluR subtype was responsible for the DHPG-induced medium ADP, we used the subtype-selective antagonists LY367385 (25 µM, mGluR1 antagonist) and MPEP (10 µM, mGluR5 antagonist).
Positive_regulation (induced) of ADP associated with antagonist
18) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.15
All of these drugs inhibited the medium ADP, suggesting the Ca2+ release is required for the medium ADP, but not the slow ADP.
Positive_regulation (required) of ADP
19) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.14
This medium-duration ADP is rapidly and reversibly induced by activation of mGluR5 and requires activation of phospholipase C (PLC) and release of calcium from internal stores.
Positive_regulation (induced) of ADP in internal
20) Confidence 0.05 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.40

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