INT196323

Context Info Confidence 0.73 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 9.10 Pain Relevance 0.32

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a) protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)

Cdkn2a (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 108 98.14 rheumatoid arthritis 54 87.32 imagery 186 57.28 cytokine 28 52.72 Inflammation 46 52.32 Inflammatory response 2 43.44 Central nervous system 12 40.24 metalloproteinase 7 18.28 Spinal cord 24 5.00 fibrosis 15 5.00

Disease Link Frequency Relevance Heat Meningioma 546 99.52 Cancer 330 99.46 Retinoblastoma 6 99.02 Arthritis 112 98.14 Apoptosis 24 96.12 Monosomy 6 91.84 Chromosome Aberrations 6 87.64 Rheumatoid Arthritis 54 87.32 Pancreatitis 4 83.40 Recurrence 6 83.12

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The majority of grade III meningiomas either show homozygous deletions of p16INK4a,p14ARF, and CDKN2B, mutations in p16INK4a and p14ARF, or lack of expression of one or more of these genes (3).

Localization (deletions) of p16INK4a associated with meningioma

1) Confidence 0.73 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.29 Pain Relevance 0

In the present study, we evaluated the effects in meningioma initiation and progression of p16Ink4a loss with retention of p19Arf in synergy with Nf2 loss.

Localization (retention) of p19Arf associated with meningioma

2) Confidence 0.73 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.23 Pain Relevance 0.03

The majority of grade III meningiomas either show homozygous deletions of p16INK4a,p14ARF, and CDKN2B, mutations in p16INK4a and p14ARF, or lack of expression of one or more of these genes (3).

Localization (deletions) of p16INK4a associated with meningioma

3) Confidence 0.73 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.28 Pain Relevance 0

The majority of grade III meningiomas either show homozygous deletions of p16INK4a,p14ARF, and CDKN2B, mutations in p16INK4a and p14ARF, or lack of expression of one or more of these genes (3).

Localization (deletions) of p14ARF associated with meningioma

4) Confidence 0.73 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.34 Pain Relevance 0

The p16INK4a/p14ARF locus encodes two distinct cell cycle inhibitory proteins, p16INK4a and p14ARF (p19Arf in the mouse) by alternative first-exon usage and alternative reading frames (20). p16INK4a arrests cells in the G1 phase of the cell cycle by binding the cyclin-dependant kinases CDK4 and CDK6 and inhibiting their ability to phosphorylate and inactivate the retinoblastoma (RB1) family of tumor suppressor proteins (22). p14ARF acts through MDM2 to stabilize and activate the key checkpoint protein p53, which can arrest cells in both G1 and G2 or induce apoptosis (20).

Localization (stabilize) of p14ARF associated with cancer, apoptosis and retinoblastoma

5) Confidence 0.73 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.26 Pain Relevance 0

The majority of grade III meningiomas either show homozygous deletions of p16INK4a,p14ARF, and CDKN2B, mutations in p16INK4a and p14ARF, or lack of expression of one or more of these genes (3).

Localization (deletions) of p14ARF associated with meningioma

6) Confidence 0.73 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.28 Pain Relevance 0

Sequencing of p16ink4a, k-ras and Rb cDNA

Localization (Sequencing) of p16ink4a

7) Confidence 0.65 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 0.67 Pain Relevance 0

Other molecules that have been demonstrated to play a role in arthritis using gene transfer in various in vitro or animal models are Csk, cathepsin L, fibronectin, galectin-1, p16INK4A, p21Cip1, SOCS3, soluble CR1, superoxide dismutase and catalase, Ras, and prothymosin ?

Localization (galectin-1) of p16INK4A associated with arthritis

8) Confidence 0.06 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 0.73 Pain Relevance 0.29

General Comments

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