INT196325

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Context Info
Confidence 0.14
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.28
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Chd7) helicase activity (Chd7) DNA binding (Chd7)
Anatomy Link Frequency
lung 2
Chd7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 5 99.84 Very High Very High Very High
Inflammation 145 99.20 Very High Very High Very High
cytokine 15 97.64 Very High Very High Very High
fibrosis 13 94.88 High High
Inflammatory response 5 36.48 Quite Low
chemokine 20 31.84 Quite Low
Paracetamol 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 77 99.98 Very High Very High Very High
INFLAMMATION 140 99.84 Very High Very High Very High
Stress 65 98.12 Very High Very High Very High
Disease 20 97.84 Very High Very High Very High
Death 10 95.44 Very High Very High Very High
Fibrosis 14 94.88 High High
Pneumonia 10 93.92 High High
Injury 45 88.68 High High
Cancer 110 84.56 Quite High
Necrosis 7 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
targeted deletion or transgenic overexpression of MT genes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MT associated with targeted disruption
1) Confidence 0.14 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.35 Pain Relevance 0
On

the other hand, lung expression of MT is reportedly induced by O3 exposure in vivo [62, 63].

Positive_regulation (induced) of Gene_expression (expression) of MT in lung
2) Confidence 0.14 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 1.10 Pain Relevance 0.20
Also, MT expression in various organs/tissues can be enhanced by inflammatory stimuli, implicating in inflammatory diseases.
Positive_regulation (enhanced) of Gene_expression (expression) of MT associated with inflammation, disease and inflammatory stimuli
3) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2679981 Disease Relevance 0.94 Pain Relevance 0.24
MT expression is induced/enhanced in various tissues by a number of physiological mediators.
Positive_regulation (induced) of Gene_expression (expression) of MT
4) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2679981 Disease Relevance 0.13 Pain Relevance 0.04
also induce hepatic MT gene expression in vivo [38–40], the roles of MT in inflammation have been focused on.
Positive_regulation (induce) of Gene_expression (expression) of MT gene associated with inflammation
5) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.78 Pain Relevance 0.14
The training set was used to evaluate the optimal LDA projection matrix, ?
Positive_regulation (optimal) of Gene_expression (projection) of LDA
6) Confidence 0.04 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2903603 Disease Relevance 0 Pain Relevance 0
It is possible that in MT100 mice, constitutive overexpression of the tgf?
Positive_regulation (overexpression) of Gene_expression (overexpression) of MT100
7) Confidence 0.04 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 0.97 Pain Relevance 0.15

General Comments

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