INT19633

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Context Info
Confidence 0.44
First Reported 1990
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.82
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1, CGA) extracellular region (GNRH1, CGA) cell-cell signaling (GNRH1, CGA)
extracellular space (GNRH1) small molecule metabolic process (CGA) cellular nitrogen compound metabolic process (CGA)
Anatomy Link Frequency
pituitary 2
hypothalamus 1
gonadal 1
GNRH1 (Homo sapiens)
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 99.64 Very High Very High Very High
Opioid 6 98.52 Very High Very High Very High
Calcium channel 3 94.16 High High
agonist 22 91.04 High High
MU agonist 1 88.16 High High
Kinase C 5 84.24 Quite High
adenocard 1 69.40 Quite High
Clonidine 1 61.08 Quite High
opiate 1 31.52 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 5 94.44 High High
Oligospermia 2 80.96 Quite High
Breast Cancer 27 76.84 Quite High
Reprotox - General 2 2 75.00 Quite High
Ovarian Cancer 1 64.72 Quite High
Advanced Or Metastatic Breast Cancer 2 60.00 Quite High
Endometriosis (extended) 7 51.72 Quite High
Male Infertility 1 44.24 Quite Low
Recurrence 1 41.60 Quite Low
Disease 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, placental kappa receptors mediate opioid regulation of hCG release from trophoblast tissue in vitro and placental GnRH plays a role in regulation of hCG secretion as well.
GnRH Regulation (regulation) of Localization (secretion) of hCG associated with opioid
1) Confidence 0.44 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.69
Native LHRH produced by the hypothalamus controls the secretion of follicle-stimulating hormone and luteinizing hormone by the pituitary gland, and hence gonadal steroid hormone production.
LHRH Regulation (controls) of in gonadal Localization (secretion) of luteinizing hormone in hypothalamus
2) Confidence 0.12 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138786 Disease Relevance 0.66 Pain Relevance 0.08
On the other hand, anti-gonadotrophin releasing hormone (GnRH) IgG and the GnRH antagonist (D-Phe2, D-Trp6)-GnRH did not influence the stimulatory effect of NE on hCG release.
GnRH Neg (not) Regulation (influence) of Localization (release) of hCG associated with antagonist
3) Confidence 0.11 Published 1993 Journal Placenta Section Abstract Doc Link 8153089 Disease Relevance 0 Pain Relevance 0.56
The regulation of Gn-RH secretion and the influence of Gn-RH on gonadotropin secretion are among the most interesting aspects of hypothalamic-pituitary function.
Gn-RH Regulation (influence) of Localization (secretion) of gonadotropin in pituitary
4) Confidence 0.03 Published 1990 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 2081088 Disease Relevance 0.16 Pain Relevance 0

General Comments

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