INT19635

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Context Info
Confidence 0.78
First Reported 1980
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.83
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SHBG)
Anatomy Link Frequency
liver 1
Sertoli cell 1
SHBG (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 6 99.60 Very High Very High Very High
Opioid 1 99.16 Very High Very High Very High
antagonist 1 94.72 High High
Pain 16 94.52 High High
Pain threshold 2 53.60 Quite High
Inflammation 34 50.00 Quite Low
Inflammatory marker 8 41.44 Quite Low
narcan 1 25.00 Low Low
beta blocker 12 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 30 98.96 Very High Very High Very High
Clinical Trials And Case Reports 4 98.32 Very High Very High Very High
Hypertension 107 95.48 Very High Very High Very High
Reprotox - General 3 2 94.64 High High
Reprotox - General 2 69 94.56 High High
Pain 17 94.52 High High
Opiate Addiction 1 94.00 High High
Disease 24 92.48 High High
Oligospermia 2 90.44 High High
Male Infertility 1 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cells secrete transferrin and ABP, and hABP has an affinity for DHT which is different from that of liver-produced SHBG.
Localization (secrete) of ABP in liver
1) Confidence 0.78 Published 1990 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 2081088 Disease Relevance 0.39 Pain Relevance 0.07
In most clinical situations the available tests are total testosterone and SHBG which are both easily and reliably measured.
Localization (measured) of SHBG
2) Confidence 0.64 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 0.24 Pain Relevance 0
Early clinical studies suggested that opiates may interfere with sex hormone secretion.
Localization (secretion) of sex hormone associated with opiate
3) Confidence 0.47 Published 1980 Journal Am J Psychiatry Section Abstract Doc Link 6774622 Disease Relevance 0.19 Pain Relevance 0.33
The present study demonstrated that green odor attenuated the increase in SBP and DBP induced by CPT and facilitated recovery of Ts without having any effect on these parameters, under non-stressful conditions.
Localization (increase) of SBP
4) Confidence 0.19 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2259378 Disease Relevance 0.64 Pain Relevance 0.64
The meta analysis showed that in five studies with the combination versus placebo, the between-group weighted mean differences (WMDs) for both SBP and DBP favored perindopril plus indapamide (SBP ?
Localization (weighted) of SBP associated with clinical trials and case reports
5) Confidence 0.10 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012553 Disease Relevance 0.41 Pain Relevance 0
Aside from sex, the strongest predictor of both SBP and DBP among Tsimane is BMI (standardized estimate?
Localization (predictor) of SBP associated with obesity
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722089 Disease Relevance 0.95 Pain Relevance 0
For example, MSHs increased cAMP accumulation and aromatase activity in these cells, while opioids inhibited Sertoli cell proliferation and androgen binding protein (ABP) secretion.
Localization (secretion) of androgen binding protein in Sertoli cell associated with opioid
7) Confidence 0.06 Published 1986 Journal Med. Biol. Section Abstract Doc Link 2939305 Disease Relevance 0 Pain Relevance 0.24

General Comments

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