INT196352

Context Info Confidence 0.06 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.91 Pain Relevance 0.58

cytoplasm (MMP14)

Anatomy Link Frequency colon 2 MMP14 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 74 100.00 COX-2 inhibitor 19 97.96 cINOD 1 73.44 aspirin 1 72.80 cytokine 1 5.00

Disease Link Frequency Relevance Heat Colon Cancer 4 99.56 Prostate Cancer 3 98.72 Cancer 27 93.72 Lung Cancer 3 91.60 Breast Cancer 56 84.24 Advanced Or Metastatic Breast Cancer 2 68.04 Disease 2 57.92 Metastasis 12 39.44 Injury 9 5.00 Apoptosis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Tsuji et al. [16] observed an increase in MMP-2 activation and increase in MMP-14 mRNA expression by Caco-2 colon cancer cells, which showed high levels of COX-2.

Positive_regulation (increase) of Transcription (expression) of MMP-14 in colon associated with colon cancer and metalloproteinase

1) Confidence 0.06 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.91 Pain Relevance 0.58

General Comments

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