INT19637

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Context Info
Confidence 0.73
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.74
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TF) extracellular region (TF) cytoplasmic membrane-bounded vesicle (TF)
transmembrane transport (TF)
Anatomy Link Frequency
myocardium 2
Tear 1
plasma 1
liver 1
bone marrow 1
TF (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 1 99.92 Very High Very High Very High
Inflammation 51 98.72 Very High Very High Very High
local anesthetic 1 92.96 High High
Pain 6 88.32 High High
rheumatoid arthritis 2 86.64 High High
opiate 1 72.40 Quite High
Inflammatory mediators 2 70.04 Quite High
withdrawal 2 68.16 Quite High
Angina 18 56.24 Quite High
antagonist 7 52.20 Quite High
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 45 99.48 Very High Very High Very High
Myocardial Infarction 96 98.78 Very High Very High Very High
INFLAMMATION 67 98.72 Very High Very High Very High
Necrosis 17 98.16 Very High Very High Very High
Atherosclerotic Plaque 3 93.04 High High
Discoid Lupus Erythematosus 6 90.96 High High
Oligospermia 2 90.44 High High
Thrombocytopenia 1 90.44 High High
Anaemia 1 89.60 High High
Arthralgia 2 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antigens reactive with these 5 sera colocalized with internalized transferrin receptors, indicating their association with early endosomes.
Localization (colocalized) of transferrin
1) Confidence 0.73 Published 1998 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9434799 Disease Relevance 0.38 Pain Relevance 0.11
The other 5 sera which did not react to both fusion proteins did not colocalize with internalized transferrin receptors.
Neg (not) Localization (colocalize) of transferrin
2) Confidence 0.73 Published 1998 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9434799 Disease Relevance 0.41 Pain Relevance 0.13
Interestingly, erythropoiesis did not seem to be limited by iron supply in patients, since serum iron and soluble transferring (Tf) receptor (sTfR) were normal.
Localization (receptor) of transferrin
3) Confidence 0.73 Published 2009 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 19268001 Disease Relevance 0.93 Pain Relevance 0.07
Since cardiomyocytes constitutively express TF and release TF positive procoagulant MP under inflammatory conditions, it is reasonable to speculate that MPs bearing TF in ongoing AMI may arise from necrotic myocardium [24,25].
Localization (release) of TF in myocardium associated with inflammation and myocardial infarction
4) Confidence 0.69 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.81 Pain Relevance 0.09
In an additional group of patients with uAP and AMI, we identified circulating microparticles as the prevailing reservoir of plasma TF activity in acute coronary syndromes.


Localization (reservoir) of TF in plasma associated with acute coronary syndrome and myocardial infarction
5) Confidence 0.69 Published 2009 Journal Thromb J Section Abstract Doc Link PMC2714503 Disease Relevance 0.75 Pain Relevance 0.06
Since cardiomyocytes constitutively express TF and release TF positive procoagulant MP under inflammatory conditions, it is reasonable to speculate that MPs bearing TF in ongoing AMI may arise from necrotic myocardium [24,25].
Localization (release) of TF in myocardium associated with inflammation and myocardial infarction
6) Confidence 0.68 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.81 Pain Relevance 0.09
Therefore, the effects of dibucaine on Fe uptake and Tf internalization were studied using myogenic cell line L6.
Localization (internalization) of Tf
7) Confidence 0.52 Published 1990 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2310774 Disease Relevance 0 Pain Relevance 0.09
These cells secrete transferrin and ABP, and hABP has an affinity for DHT which is different from that of liver-produced SHBG.
Localization (secrete) of transferrin in liver
8) Confidence 0.46 Published 1990 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 2081088 Disease Relevance 0.39 Pain Relevance 0.07
Any TF, TM and D-D present was sandwiched by the immobilized capture antibody and the enzyme-linked monoclonal antibody specific for these analytes.
Localization (present) of TF
9) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0 Pain Relevance 0
1 within the endometrium plays a critical role in triggering the process of menstruation in cells from non-pregnant endometrium by inhibiting biosynthesis and/or secretion of PRL, IGFBP-1 and tissue factor (TF) via a SMAD-dependent pathway.
Localization (secretion) of TF in endometrium
10) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0.17 Pain Relevance 0.03
Adesida et al. utilized a micromass-like methodology, but this required that the culture be carried out with supplemented chondrogenic factors (insulin, transferrin, selenite, dexamethasone, TGF-?)
Localization (selenite) of transferrin associated with dexamethasone
11) Confidence 0.15 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0.07 Pain Relevance 0.05
Orthopedic surgery due to surgical damage to bone is especially prone to TF release because bone marrow is rich in TF (Dahl et al 1995).
Localization (release) of TF in bone marrow
12) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.07 Pain Relevance 0
An invasive operative procedure cannot be performed without tissue damage resulting in release of tissue factor (TF).
Localization (release) of TF
13) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.07 Pain Relevance 0.03
Tear protein profiles have historically been characterized using gel electrophoresis and immunoblot, which have shown the major constituents to include lysozyme, lactoferrin, secretory IgA, Ig E, lipocalin, serum albumin, transferrin, and lipophilin [9-15].
Localization (secretory) of transferrin in Tear
14) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965574 Disease Relevance 0.87 Pain Relevance 0.04

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