INT196375

Context Info Confidence 0.08 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.73 Pain Relevance 0

mitochondrion (Ppox) oxidoreductase activity (Ppox)

Ppox (Mus musculus)

Pain Link Frequency Relevance Heat abdominal pain 3 49.36 peripheral neuropathy 2 44.32 Central nervous system 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Variegate Porphyria 43 99.96 Porphyria 48 97.28 Acute Intermittent Porphyria 5 97.08 Hereditary Coproporphyria 1 96.72 Hepatic Porphyrias 10 93.04 Syndrome 3 86.76 Disease 58 84.84 Death 2 72.24 Neurodegenerative Disease 3 69.92 Anxiety Disorder 2 63.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A partial deficiency in Protoporphyrinogen oxidase (PPOX) produces the mixed disorder Variegate Porphyria (VP), the second acute porphyria more frequent in Argentina.

Negative_regulation (deficiency) of Protoporphyrinogen oxidase associated with variegate porphyria and acute intermittent porphyria

1) Confidence 0.08 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2467414 Disease Relevance 0.62 Pain Relevance 0

coproporphyrinogen oxidase, EC 1.3.3.3), and variegate porphyria (deficiency of protoporphyrinogen oxidase, EC 1.3.3.4).

Negative_regulation (deficiency) of protoporphyrinogen oxidase associated with variegate porphyria

2) Confidence 0.04 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559910 Disease Relevance 2.12 Pain Relevance 0

General Comments

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