INT196377

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 5.97
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion organization (Nrf1) nucleus (Nrf1) DNA binding (Nrf1)
cytoplasm (Nrf1)
Anatomy Link Frequency
skeletal muscle 3
cortex 1
hippocampus 1
Nrf1 (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 492 98.68 Very High Very High Very High
Hippocampus 26 97.76 Very High Very High Very High
cytokine 18 91.36 High High
abdominal pain 2 90.00 High High
Acupuncture 60 82.20 Quite High
peripheral neuropathy 2 82.00 Quite High
Osteoarthritis 6 78.72 Quite High
Fibrositis 6 77.72 Quite High
Spinal cord 6 77.68 Quite High
Pain 6 77.16 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 156 96.88 Very High Very High Very High
Sprains And Strains 12 93.96 High High
Aging 55 92.24 High High
Diabetes Mellitus 88 91.64 High High
Obesity 74 91.28 High High
Abdominal Pain 2 90.00 High High
Hyperglycemia 18 89.36 High High
Psychosis 3 88.48 High High
Cognitive Disorder 73 83.52 Quite High
Peripheral Neuropathy 2 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
is a coactivator for NRF1 expression [24], discrepancy between induced PGC-1?
Gene_expression (expression) of NRF1
1) Confidence 0.68 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.34 Pain Relevance 0.19
The resultant increase in expression of mitochondrial genes, including NRF1, may exert positive effects on insulin signaling [12] (Figure 4).
Gene_expression (expression) of NRF1
2) Confidence 0.68 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.44 Pain Relevance 0.25
, NRF1, and ACOX gene expression.
Gene_expression (expression) of NRF1
3) Confidence 0.59 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 1.01 Pain Relevance 0.63
NRF1 gene expression in the skeletal muscle of db/db mice decreased significantly compared with db/m mice, whereas it increased by two folds to four folds in EA-treated db/db mice compared with the expression in untreated littermates (Figure 3(c)).
Gene_expression (expression) of NRF1 gene in skeletal muscle associated with electroacupuncture
4) Confidence 0.53 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0 Pain Relevance 0.22
, nuclear respiratory factor 1 (NRF1), and acyl-CoA oxidase (ACOX) gene expression in the skeletal muscle of db/db mice.
Gene_expression (expression) of NRF1 in skeletal muscle
5) Confidence 0.53 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.43 Pain Relevance 0.43
, nuclear respiratory factor 1 (NRF1), and acyl-CoA oxidase (ACOX) gene expression in the skeletal muscle of db/db mice.
Gene_expression (expression) of nuclear respiratory factor 1 in skeletal muscle
6) Confidence 0.53 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.44 Pain Relevance 0.43
factors NRF-1 and FOXO1 [14,
Gene_expression (factors) of NRF-1
7) Confidence 0.09 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559910 Disease Relevance 0.48 Pain Relevance 0.13
We found that expression of Nox2, the respiratory burst oxidase, was significantly increased in neurons throughout the hippocampus and cortex in aged mouse brain, as documented by immunocytochemistry, Western blot analysis, and mRNA (data not shown).
Gene_expression (expression) of respiratory burst oxidase in cortex associated with hippocampus
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 1.41 Pain Relevance 0.17
We found that expression of Nox2, the respiratory burst oxidase, was significantly increased in neurons throughout the hippocampus and cortex in aged mouse brain, as documented by immunocytochemistry, Western blot analysis, and mRNA (data not shown).
Gene_expression (expression) of respiratory burst oxidase in hippocampus associated with hippocampus
9) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 1.41 Pain Relevance 0.17

General Comments

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