INT19639

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Context Info
Confidence 0.55
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 19
Disease Relevance 7.69
Pain Relevance 5.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 8
blood 4
plasma 2
endothelial cells 2
polymorphonuclear leukocytes 2
Tbxa2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 30 100.00 Very High Very High Very High
local anesthetic 6 99.96 Very High Very High Very High
Paracetamol 7 99.72 Very High Very High Very High
aspirin 35 99.54 Very High Very High Very High
cva 29 99.16 Very High Very High Very High
tolerance 1 97.44 Very High Very High Very High
cINOD 58 94.26 High High
Potency 2 88.64 High High
Pain 37 86.24 High High
corticosteroid 2 82.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 41 100.00 Very High Very High Very High
Injury 4 99.84 Very High Very High Very High
Cv General 4 Under Development 19 99.16 Very High Very High Very High
Increased Venous Pressure Under Development 34 98.88 Very High Very High Very High
Hypertension 9 97.92 Very High Very High Very High
Syndrome 3 97.68 Very High Very High Very High
Cv General 3 Under Development 13 96.76 Very High Very High Very High
Pressure And Volume Under Development 10 95.84 Very High Very High Very High
Pseudomonas Infection 1 95.32 Very High Very High Very High
Disease 19 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet aggregation and TXA2 synthesis were inhibited in a similar manner.
Negative_regulation (inhibited) of Gene_expression (synthesis) of TXA2 in Platelet
1) Confidence 0.55 Published 1990 Journal Drugs Section Abstract Doc Link 2081487 Disease Relevance 0.21 Pain Relevance 0.32
Local anesthetics (LA) inhibit signaling of TXA2 receptors expressed in cell models.
Negative_regulation (inhibit) of Gene_expression (expressed) of TXA2
2) Confidence 0.42 Published 2000 Journal Reg Anesth Pain Med Section Abstract Doc Link 10746533 Disease Relevance 0.17 Pain Relevance 0.30
Local anesthetics (LA) inhibit signaling of TXA2 receptors expressed in cell models.
Negative_regulation (inhibit) of Gene_expression (expressed) of TXA2 associated with local anesthetic
3) Confidence 0.38 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15281511 Disease Relevance 0.60 Pain Relevance 0.39
However, CoBF oscillation which developed after inhibition of NO synthesis could not be reversed completely by inhibition of TXA2 synthesis, raising the possibility that other mediators may also be involved in this process.
Negative_regulation (inhibition) of Gene_expression (synthesis) of TXA2
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.06 Pain Relevance 0
The antithrombotic property of aspirin is mainly related to its irreversible inhibition of the production of platelet-derived thromboxane A2, which possesses aggregatory and vasoconstrictive properties.
Negative_regulation (inhibition) of Gene_expression (production) of thromboxane A2 in platelet associated with aspirin
5) Confidence 0.34 Published 1997 Journal Tidsskr. Nor. Laegeforen. Section Abstract Doc Link 9456592 Disease Relevance 0.72 Pain Relevance 0.47
NO reportedly suppresses the synthesis of TXA2 [29] and inhibition of NOS was recently reported to enhance TXA2 release also from cerebrovascular endothelial cells [17].
Negative_regulation (suppresses) of Gene_expression (synthesis) of TXA2 in endothelial cells
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.73 Pain Relevance 0.12
All three drugs inhibited production of 6-keto prostaglandin F1 alpha and thromboxane B2 in wound fluid and concomitantly restored the bactericidal activity of polymorphonuclear leukocytes (PMNLs) against Pseudomonas aeruginosa to normal.
Negative_regulation (inhibited) of Gene_expression (production) of thromboxane B2 in polymorphonuclear leukocytes associated with pseudomonas infection and injury
7) Confidence 0.27 Published 1988 Journal J. Infect. Dis. Section Abstract Doc Link 3129524 Disease Relevance 0.64 Pain Relevance 0.07
Serum thromboxane B2 production was significantly (P = 0.05) suppressed for 12, 8, and 24 hours after administration of flunixin, phenylbutazone, and the drugs in combination, respectively.
Negative_regulation (suppressed) of Gene_expression (production) of thromboxane B2
8) Confidence 0.27 Published 1993 Journal Am. J. Vet. Res. Section Abstract Doc Link 8291770 Disease Relevance 0.40 Pain Relevance 0.20
U-46619 significantly augmented the CBF-oscillations induced by L-NAME while inhibition of endogenous TXA2 synthesis by ozagrel (10 mg/kg iv.) attenuated it.
Negative_regulation (inhibition) of Gene_expression (synthesis) of TXA2
9) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3013104 Disease Relevance 0.15 Pain Relevance 0.04
Bepridil also significantly decreased the plasma levels of thromboxane B2 and leukotriene C4 at rest.
Negative_regulation (decreased) of Gene_expression (levels) of thromboxane B2 in plasma
10) Confidence 0.25 Published 1994 Journal Am. J. Cardiol. Section Abstract Doc Link 8198031 Disease Relevance 0.53 Pain Relevance 0.26
Nabumetone administration also resulted in the inhibition of platelet TXA2 synthesis, whereas aortic PGI2 synthesis was unaltered.
Negative_regulation (inhibition) of Gene_expression (synthesis) of TXA2 in platelet
11) Confidence 0.24 Published 1990 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2281122 Disease Relevance 0.20 Pain Relevance 0.33
Yet, administration to unanaesthetized newborn rats of acetaminophen, a drug that inhibits the synthesis of PGE2 and thromboxane B2, blocked, rather than enhanced, the increment in urine osmolality produced by 1 h of water deprivation.
Negative_regulation (inhibits) of Gene_expression (synthesis) of thromboxane B2 in urine associated with paracetamol
12) Confidence 0.08 Published 1990 Journal Pediatr. Nephrol. Section Abstract Doc Link 2088466 Disease Relevance 0.07 Pain Relevance 0.10
Aspirin exerts anti-thrombotic action by acetylating and inactivating cyclooxygenase-1, preventing the production of thromboxane A2 in platelets.
Negative_regulation (preventing) of Gene_expression (production) of thromboxane A2 in platelets associated with aspirin
13) Confidence 0.07 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18038215 Disease Relevance 0.39 Pain Relevance 0.33
SK&F 105809 inhibited LTB4 and PGE2 production in vivo in inflammatory exudates as well as the production of LTB4 and thromboxane B2 (TxB2) ex vivo in rat blood.
Negative_regulation (inhibited) of Gene_expression (production) of thromboxane B2 in blood associated with inflammation
14) Confidence 0.04 Published 1990 Journal Drugs Exp Clin Res Section Abstract Doc Link 2127565 Disease Relevance 0.85 Pain Relevance 0.31
Levels of thromboxane B2 (TXB2), the catabolite of TXA2, were reduced in treated animals at 6 and 12 hours but these changes were not significant.
Negative_regulation (reduced) of Gene_expression (Levels) of thromboxane B2
15) Confidence 0.03 Published 1984 Journal Cornell Vet Section Abstract Doc Link 6587959 Disease Relevance 0.26 Pain Relevance 0.25
Administration of low dose aspirin 40 mg/day selectively inhibits production of thromboxane A2 without affecting prostacyclin.
Negative_regulation (inhibits) of Gene_expression (production) of thromboxane A2 associated with aspirin
16) Confidence 0.01 Published 1987 Journal Drugs Section Abstract Doc Link 3595474 Disease Relevance 0.71 Pain Relevance 0.70
In addition, 15,16-Dihydrotanshinone I at 50 microM slightly but significantly inhibited collagen-induced production of thromboxane B2.
Negative_regulation (inhibited) of Gene_expression (production) of thromboxane B2
17) Confidence 0.01 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 18277607 Disease Relevance 0.31 Pain Relevance 0.10
All selective and traditional NSAIDs inhibit prostanoid biosynthesis (Warner and Mitchell 2004); however, it has been hypothesized that selective suppression of COX-2-dependent synthesis of prostacyclin (a vasodilator and inhibitor of platelet aggregation and vascular smooth muscle cell proliferation) without concomitant inhibition of COX-1-dependent synthesis of thromboxane A2 (a vasoconstrictor and promoter of platelet aggregation and vascular proliferation), may increase the risk of cardiovascular adverse effects owing to thromboembolism or elevated blood pressure in patients predisposed to such events (Fitz Gerald 2002, 2004; Clark et al 2004; Warner and Mitchell 2004).
Negative_regulation (inhibition) of Gene_expression (synthesis) of thromboxane A2 in blood associated with pressure and volume under development, cinod and cva
18) Confidence 0.01 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661646 Disease Relevance 0.60 Pain Relevance 0.72
Inhibition of thromboxane B2 production, measured by use of a radioimmunoassay, was taken as a marker of COX-1 and COX-2 activities.
Negative_regulation (Inhibition) of Gene_expression (production) of thromboxane B2
19) Confidence 0.00 Published 2005 Journal Am. J. Vet. Res. Section Body Doc Link 15900953 Disease Relevance 0.08 Pain Relevance 0

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